{"id":"W4401383859","doi":"10.1200/jco.24.00709","title":"Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; McGill University; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute","keywords":"Medicine; Oncology; Pharmacology; Internal medicine; Family medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1202087,0.001544826,0.003667678,0.002145856,0.00412986,0.009047655,0.009336103,0.05650916,0.009965723],"category_scores_gemma":[0.4225919,0.001735853,0.005380013,0.003455183,0.009187827,0.01393709,0.004934172,0.05927906,0.007088312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00664601,"about_ca_system_score_gemma":0.01468546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005796981,"about_ca_topic_score_gemma":0.007625062,"domain_scores_codex":[0.909978,0.04128352,0.02205343,0.005943556,0.01781416,0.00292735],"domain_scores_gemma":[0.47575,0.3849786,0.03068689,0.01199508,0.07862453,0.01796502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002117351,0.00002433044,0.0003734533,0.0006025722,0.00009128828,0.0003723896,0.000238483,0.00008646019,0.0001169667,0.002668513,0.9798738,0.01533993],"study_design_scores_gemma":[0.0004040007,0.0002005338,0.0007068964,0.002820703,0.000261115,0.0009034128,0.0006468837,0.0002551641,0.0004636673,0.009617187,0.9835832,0.0001372167],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001204034,0.003644725,0.0002095723,0.9615282,0.03366646,0.00002972319,0.00009508535,0.00003316528,0.000672652],"genre_scores_gemma":[0.001251022,0.001771973,0.0006514118,0.942762,0.05274638,0.00006627701,0.00004412054,0.00004241381,0.0006643601],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1202087,"threshold_uncertainty_score":0.6357317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3532963520517678,"score_gpt":0.575118782852302,"score_spread":0.2218224308005342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}