{"id":"W4401385117","doi":"10.1007/s13555-024-01242-9","title":"More Time Spent with Clear Skin and No Itch with Upadacitinib versus Dupilumab for Atopic Dermatitis","year":2024,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; Queen's University","funders":"Janssen Pharmaceuticals; LEO Pharma; Coherus Biosciences; Argenx; Daewoong Pharmaceutical Company; Sanofi Genzyme; Pfizer; Incyte; National Eczema Association; Celldex Therapeutics; Dermira; Sun Pharma; Regeneron Pharmaceuticals; Kiniksa Pharmaceuticals; AbbVie; Sanofi; GlaxoSmithKline; Celgene; Galderma; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amgen; Castle Biosciences","keywords":"Dupilumab; Atopic dermatitis; Medicine; Dermatology; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003629587,0.0001998583,0.0003680524,0.00008687921,0.0001444339,0.00003434858,0.00004774259,0.0001458742,0.0001380432],"category_scores_gemma":[0.00001018847,0.0001344147,0.00004399592,0.0000819675,0.0003728939,0.0001056522,0.00001451733,0.0001481974,0.00005407258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008746198,"about_ca_system_score_gemma":0.00008070024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006458117,"about_ca_topic_score_gemma":0.000006698803,"domain_scores_codex":[0.9991477,0.0000397576,0.0001582405,0.0003050027,0.0000909005,0.0002583804],"domain_scores_gemma":[0.9993965,0.0002244992,0.0000329545,0.0001672072,0.00005381307,0.0001250452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05545782,0.001388946,0.4899978,0.005776691,0.009355575,0.01734249,0.007895023,0.000005040329,0.0004898718,0.02671099,0.268994,0.1165858],"study_design_scores_gemma":[0.03871096,0.002199226,0.1473877,0.00081662,0.0008016087,0.04527556,0.0006435683,0.003161635,0.004836942,0.001519868,0.7536261,0.001020142],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768459,0.01283147,0.0001626595,0.006743382,0.0001353842,0.0006043511,0.00002669201,0.0001358003,0.002514322],"genre_scores_gemma":[0.9954665,0.001402746,0.0004911313,0.001921758,0.00005748513,0.00008365251,0.00007009711,0.00003162497,0.0004750061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4846322,"threshold_uncertainty_score":0.5481271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093153645027651,"score_gpt":0.2685414857762176,"score_spread":0.2576099493259411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}