{"id":"W4401413118","doi":"10.1038/s41420-024-02118-9","title":"Fatty links between multisystem proteinopathy and small VCP-interacting protein","year":2024,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Government of Canada; ALS Society of Canada","keywords":"Myristoylation; Amyotrophic lateral sclerosis; Cell biology; Frontotemporal dementia; Protein aggregation; Autophagy; Chemistry; Biology; Cancer research; Dementia; Biochemistry; Medicine; Disease; Apoptosis; Phosphorylation; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497945,0.0003758011,0.0001394332,0.0003725402,0.0002013408,0.00021362,0.0001803674,0.0003432887,0.002432722],"category_scores_gemma":[0.0002040075,0.0001203904,0.0001281563,0.0002129241,0.0003079432,0.0002022563,0.0004600265,0.0003269148,0.0002996686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002644614,"about_ca_system_score_gemma":0.0001483553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003110636,"about_ca_topic_score_gemma":0.000374625,"domain_scores_codex":[0.9999179,0.00002256636,0.00001111074,0.00001772158,0.00001905603,0.00001166923],"domain_scores_gemma":[0.999824,0.00004172292,0.00007778738,0.00001124942,0.00001458239,0.00003064882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001575774,0.0001421511,0.01710675,0.00031303,0.0001219892,0.01748827,0.00008681338,0.0002991078,0.9456906,0.0039454,0.0005287349,0.01270139],"study_design_scores_gemma":[0.0002760299,0.001580367,0.1327292,0.00008305574,0.0003143139,0.07292797,0.000233336,0.002643233,0.7534296,0.00665897,0.02908792,0.00003599991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827757,0.009779508,0.002922917,0.0004534358,0.00007250735,0.00002872847,0.0001601039,0.00005616903,0.003750925],"genre_scores_gemma":[0.9949855,0.002013165,0.0009201465,0.0000817801,0.00003442922,0.00001522534,0.0001462072,0.000004716085,0.001798933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002432722,"threshold_uncertainty_score":0.008138299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256818658532185,"score_gpt":0.2399441353541248,"score_spread":0.227375948768803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}