{"id":"W4401416872","doi":"10.1126/science.adp2065","title":"Regulation of the hematopoietic stem cell pool by C-Kit–associated trogocytosis","year":2024,"lang":"en","type":"article","venue":"Science","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Leukemia and Lymphoma Society; Fonds de Recherche du Québec - Santé; National Institutes of Health; European Commission; Bayer HealthCare; Cancer Research Institute; Ironwood Pharmaceuticals, Incorporated; Edward P. Evans Foundation; Celgene; GlaxoSmithKline; New York Stem Cell Foundation","keywords":"Stem cell; Haematopoiesis; Biology; Cell biology; Hematopoietic stem cell; Bone marrow; Stem cell factor; Proto-Oncogene Proteins c-kit; Macrophage; Adult stem cell; Endothelial stem cell; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339784,0.0001946117,0.0001284097,0.0002541358,0.00009197117,0.0003158618,0.0001288563,0.0001713739,0.0008330466],"category_scores_gemma":[0.0001161125,0.00007521808,0.0001173863,0.0000859722,0.0002229151,0.0001567,0.000290124,0.0003507799,0.0001717989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000155141,"about_ca_system_score_gemma":0.00013959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001413794,"about_ca_topic_score_gemma":0.0002811511,"domain_scores_codex":[0.9998826,0.00003040449,0.000009318849,0.00002028747,0.00002715919,0.00003022767],"domain_scores_gemma":[0.9999107,0.00002018458,0.00003303196,0.000008096344,0.000007892428,0.00002006243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004789256,0.00000852046,0.0002536299,0.00001583984,0.000001865908,0.00004449521,0.00001229651,0.00003140607,0.9982584,0.0002151994,0.00001465496,0.001095778],"study_design_scores_gemma":[0.00001420536,0.0002004359,0.006892055,0.000009392911,0.00001145286,0.0003292226,0.00003852824,0.0009210121,0.9895858,0.00008229719,0.001912392,0.000003306202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955961,0.001039141,0.002244256,0.00003496114,0.000005144846,0.00001863847,0.000073627,0.00003831218,0.0009498597],"genre_scores_gemma":[0.9976892,0.0004606414,0.001032892,0.00001840575,0.000004099511,0.00002115352,0.00008445825,0.000008821312,0.0006802743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008330466,"threshold_uncertainty_score":0.002786756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218754474735842,"score_gpt":0.2527963492008573,"score_spread":0.2406088044534989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}