{"id":"W4401417716","doi":"10.3390/pathogens13080668","title":"Aggregatibacter actinomycetemcomitans Dispersin B: The Quintessential Antibiofilm Enzyme","year":2024,"lang":"en","type":"review","venue":"Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kane Biotech (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of California, San Francisco; National Institutes of Health","keywords":"Aggregatibacter actinomycetemcomitans; Microbiology; Enzyme; Chemistry; Biology; Biochemistry; Bacteria; Genetics; Porphyromonas gingivalis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002649447,0.0006388579,0.0008648101,0.00007943745,0.0001846886,0.0002219994,0.0004606493,0.0006014688,0.00006183964],"category_scores_gemma":[0.00006437558,0.0003851667,0.00109966,0.0002150707,0.00016445,0.000004161857,0.0003828145,0.0004608006,0.0003174943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003696916,"about_ca_system_score_gemma":0.0002299162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001380392,"about_ca_topic_score_gemma":0.00002997506,"domain_scores_codex":[0.9977117,0.0002359804,0.000535074,0.000821517,0.0001630219,0.0005326951],"domain_scores_gemma":[0.9986379,0.0000361479,0.0002520354,0.0009042969,0.0000516183,0.0001180174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002861056,0.00007134549,0.000004241073,0.004652349,0.0009791704,0.0001233371,0.00008349636,1.621843e-7,0.1956525,0.0001627328,0.01966315,0.7785789],"study_design_scores_gemma":[0.00007140196,0.00006607553,0.000001830499,0.002024159,0.00129371,0.0003599812,0.00002651448,0.000002005272,0.002946013,0.000002350183,0.9927092,0.0004967155],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007993699,0.9946204,0.00001473874,0.0001100061,0.0021052,0.0005375613,0.0005771681,0.00004213028,0.001193363],"genre_scores_gemma":[0.001483622,0.9926289,0.0001370863,0.0001075347,0.002712035,0.0000194496,0.001047447,0.0001478848,0.001716088],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9730461,"threshold_uncertainty_score":0.99986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549959473272334,"score_gpt":0.2965407584141611,"score_spread":0.2710411636814377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}