{"id":"W4401417716","doi":"10.3390/pathogens13080668","title":"Aggregatibacter actinomycetemcomitans Dispersin B: The Quintessential Antibiofilm Enzyme","year":2024,"lang":"en","type":"review","venue":"Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kane Biotech (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of California, San Francisco; National Institutes of Health","keywords":"Aggregatibacter actinomycetemcomitans; Microbiology; Enzyme; Chemistry; Biology; Biochemistry; Bacteria; Genetics; Porphyromonas gingivalis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340391,0.0006588017,0.0005025656,0.0006262554,0.0001209968,0.0003720133,0.0002023956,0.000278036,0.0003121738],"category_scores_gemma":[0.0001236825,0.0001129385,0.0002233603,0.0005511913,0.0001140035,0.00031183,0.0001312135,0.0001749666,0.0003157227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003286127,"about_ca_system_score_gemma":0.0003044548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009834911,"about_ca_topic_score_gemma":0.001033862,"domain_scores_codex":[0.999899,0.00001118322,0.00001618926,0.00001983985,0.00004165969,0.00001203513],"domain_scores_gemma":[0.999945,0.000008137448,0.00002076825,0.000002294458,0.00001699921,0.00000676884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002211483,0.00006502429,0.001390002,0.00608043,0.00006822687,0.0008263286,0.00006199882,0.0007246769,0.7253252,0.0006050371,0.002064269,0.2625676],"study_design_scores_gemma":[0.00004912799,0.00155621,0.02359872,0.0008323677,0.000407377,0.005951879,0.0001242442,0.0009941588,0.4931431,0.0004999017,0.472781,0.00006200997],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05792236,0.9346716,0.002855645,0.0002439089,0.0002188805,0.00003865036,0.0002063732,0.0000759468,0.003766577],"genre_scores_gemma":[0.181907,0.8060033,0.004976389,0.0003333013,0.0001996274,0.00005036571,0.0007021753,0.00001470482,0.005813063],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0009834911,"threshold_uncertainty_score":0.002384305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549959473272334,"score_gpt":0.2965407584141611,"score_spread":0.2710411636814377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}