{"id":"W4401420229","doi":"10.1016/j.cell.2024.05.059","title":"Guidelines for minimal information on cellular senescence experimentation in vivo","year":2024,"lang":"en","type":"review","venue":"Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute on Aging; Agencia Estatal de Investigación; Fonds de Recherche du Québec - Santé; National Institutes of Health; European Commission; Universität für Bodenkultur Wien; Buck Institute for Research on Aging; Herzfelder'sche Familienstiftung; General Secretariat for Research and Technology; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Medical Research Council; Regione Lombardia; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; Glenn Foundation for Medical Research; Austrian Science Fund; Fondazione Regionale per la Ricerca Biomedica; ZonMw; Associazione Italiana per la Ricerca sul Cancro; Cancer Research Society; Imperial College London; Biotechnology and Biological Sciences Research Council; Cancer Research UK; Natural Sciences and Engineering Research Council of Canada; Pfizer; Noaber Foundation; National Cancer Institute; Ludwig Boltzmann Gesellschaft; Ovarian Cancer Canada; European Regional Development Fund; Merck KGaA; Zentrum für Regenerative Therapien Dresden; Allgemeine Unfallversicherungsanstalt; Brown University; Deutsche Forschungsgemeinschaft","keywords":"Biology; Senescence; In vivo; Cell biology; Cellular senescence; Computational biology; Genetics; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002398374,0.0003916825,0.0009281699,0.0004775463,0.00003639561,0.00005137171,0.0001385488,0.0002806885,0.00007304958],"category_scores_gemma":[0.0001292853,0.0003042288,0.0003333736,0.000356907,0.00003183914,0.0001518886,0.00003178869,0.0002468767,0.0003922112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983116,"about_ca_system_score_gemma":0.0003250831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002198469,"about_ca_topic_score_gemma":0.000002417578,"domain_scores_codex":[0.9980435,0.00003635225,0.001004094,0.0003497575,0.0002853388,0.0002809586],"domain_scores_gemma":[0.9990723,0.00009312633,0.0002341467,0.0003294014,0.0001692823,0.0001018047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001095846,0.0002097755,0.000006783066,0.1083059,0.00006068683,0.00008406283,0.001317157,0.000002438788,0.001885796,0.000118242,0.07376262,0.814137],"study_design_scores_gemma":[0.0004517989,0.000181431,0.000001010095,0.01207092,0.0003727505,0.00001391378,0.0002272985,0.00012205,0.005559321,0.000006679653,0.9807108,0.0002820172],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001027828,0.9952708,0.0003158147,0.000104101,0.000847173,0.001763785,0.00007827517,0.00008077121,0.001436519],"genre_scores_gemma":[0.00009275076,0.9938926,0.001589283,0.0004151038,0.000480601,0.0003132693,0.0005429669,0.00005209601,0.002621314],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9069482,"threshold_uncertainty_score":0.999941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234437132244198,"score_gpt":0.408830477122366,"score_spread":0.2853867638979462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}