{"id":"W4401420229","doi":"10.1016/j.cell.2024.05.059","title":"Guidelines for minimal information on cellular senescence experimentation in vivo","year":2024,"lang":"en","type":"review","venue":"Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute on Aging; Agencia Estatal de Investigación; Fonds de Recherche du Québec - Santé; National Institutes of Health; European Commission; Universität für Bodenkultur Wien; Buck Institute for Research on Aging; Herzfelder'sche Familienstiftung; General Secretariat for Research and Technology; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Medical Research Council; Regione Lombardia; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; Glenn Foundation for Medical Research; Austrian Science Fund; Fondazione Regionale per la Ricerca Biomedica; ZonMw; Associazione Italiana per la Ricerca sul Cancro; Cancer Research Society; Imperial College London; Biotechnology and Biological Sciences Research Council; Cancer Research UK; Natural Sciences and Engineering Research Council of Canada; Pfizer; Noaber Foundation; National Cancer Institute; Ludwig Boltzmann Gesellschaft; Ovarian Cancer Canada; European Regional Development Fund; Merck KGaA; Zentrum für Regenerative Therapien Dresden; Allgemeine Unfallversicherungsanstalt; Brown University; Deutsche Forschungsgemeinschaft","keywords":"Biology; Senescence; In vivo; Cell biology; Cellular senescence; Computational biology; Genetics; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.009220319,0.00159796,0.002523931,0.004297727,0.0008151722,0.002279029,0.004780993,0.005783845,0.02657173],"category_scores_gemma":[0.01078005,0.001114252,0.002105201,0.002906662,0.001521167,0.003367453,0.002646305,0.00465914,0.0213864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001727879,"about_ca_system_score_gemma":0.005457644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002085686,"about_ca_topic_score_gemma":0.003342,"domain_scores_codex":[0.9929356,0.002338799,0.001745697,0.000404098,0.002249023,0.0003267929],"domain_scores_gemma":[0.9911408,0.004454405,0.000938041,0.000699971,0.002482331,0.0002845832],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002131793,0.0001923798,0.0001033524,0.04523162,0.00006857661,0.0005918485,0.0004816984,0.0004011289,0.009506741,0.05071685,0.4283617,0.4641309],"study_design_scores_gemma":[0.0000134598,0.00003052525,0.00008438627,0.002988541,0.00002130026,0.000188464,0.00002539205,0.00001773753,0.0006593254,0.001604974,0.9943552,0.00001073772],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.001368287,0.7804403,0.04365189,0.02457975,0.01152897,0.004160078,0.01022103,0.002869481,0.1211802],"genre_scores_gemma":[0.007652397,0.7377707,0.09800836,0.03605063,0.003356243,0.01063429,0.02125875,0.0009144158,0.08435429],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.9907797,"threshold_uncertainty_score":0.08889127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234437132244198,"score_gpt":0.408830477122366,"score_spread":0.2853867638979462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}