{"id":"W4401429946","doi":"10.1080/14796694.2024.2368952","title":"A plain language summary of the results from the phase 2b HERIZON-BTC-01 study of zanidatamab in participants with HER2-amplified biliary tract cancer","year":2024,"lang":"en","type":"article","venue":"Future Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Biliary tract cancer; Biliary tract; Internal medicine; Phase (matter); Oncology; Cancer; Gemcitabine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007295025,0.001591614,0.002560067,0.00184322,0.0007449857,0.002070613,0.001084414,0.001896563,0.0635229],"category_scores_gemma":[0.0250324,0.0006836408,0.0032579,0.001838043,0.000313507,0.001227356,0.0005922206,0.002738072,0.01206422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001529001,"about_ca_system_score_gemma":0.002203134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004826143,"about_ca_topic_score_gemma":0.006323416,"domain_scores_codex":[0.9948254,0.002233038,0.001309012,0.0003486352,0.0009594418,0.0003246005],"domain_scores_gemma":[0.9706483,0.01734347,0.004602003,0.0005135864,0.005951396,0.0009411658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.009565167,0.0003246733,0.003421108,0.01621163,0.001052982,0.0002712711,0.0001327318,0.0003299504,0.0007224926,0.0003187924,0.9138814,0.05376781],"study_design_scores_gemma":[0.01284417,0.009166646,0.05821007,0.01510062,0.004889755,0.001244553,0.0005979205,0.0004853465,0.002075432,0.002087771,0.8929406,0.0003571714],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.02119195,0.09630603,0.008798073,0.1039003,0.04416382,0.0119768,0.6558689,0.001978258,0.05581589],"genre_scores_gemma":[0.1081059,0.105348,0.02085998,0.3291494,0.04416623,0.02631147,0.2709836,0.001291002,0.09378444],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0635229,"threshold_uncertainty_score":0.2125053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0364592644706835,"score_gpt":0.3559914022592067,"score_spread":0.3195321377885232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}