{"id":"W4401435878","doi":"10.1093/bjd/ljae266.097","title":"724 - A phase 2b, randomized, double-blinded, parallel-group, placebo-controlled study to evaluate the efficacy and safety of rezpegaldesleukin in adults with severe to very-severe alopecia areata","year":2024,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology; University of Toronto","funders":"","keywords":"Alopecia areata; Medicine; Hair loss; Placebo; Atopic dermatitis; Internal medicine; Dermatology; Psoriasis; Gastroenterology; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002273377,0.002403299,0.003800129,0.0005408994,0.0006337575,0.001128144,0.001196185,0.00248525,0.0122481],"category_scores_gemma":[0.001255176,0.0008886458,0.00158988,0.0003733672,0.001256659,0.001229071,0.0003733786,0.002937027,0.00215378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007444452,"about_ca_system_score_gemma":0.001463665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000629854,"about_ca_topic_score_gemma":0.001272159,"domain_scores_codex":[0.9991832,0.0003852978,0.00005118329,0.0001654671,0.00008156859,0.0001331817],"domain_scores_gemma":[0.9992902,0.0001450136,0.0001421103,0.00006001515,0.00008312357,0.0002794124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9454146,0.02761343,0.0004710125,0.0008512301,0.0006373835,0.00005954891,0.00004259264,0.0001925804,0.007333683,0.0001041498,0.001055754,0.01622415],"study_design_scores_gemma":[0.8940819,0.1041967,0.0006486686,0.00001541215,0.0001206892,0.00002374566,0.000007953367,0.0001442885,0.0002371224,0.00005118342,0.0004630301,0.000009322748],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583856,0.007133019,0.001756975,0.0009805292,0.001114275,0.02377389,0.002554386,0.0003897626,0.003911553],"genre_scores_gemma":[0.9500623,0.003782935,0.004643593,0.003145208,0.001227553,0.02683144,0.002320987,0.00006156378,0.007924466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0122481,"threshold_uncertainty_score":0.04097396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483900678540858,"score_gpt":0.3063250185711446,"score_spread":0.2914860117857361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}