{"id":"W4401436015","doi":"10.1093/bjd/ljae266.070","title":"696 - Sustained improvements over 140 weeks in signs, symptoms, and quality of life with upadacitinib in adolescents and adults with moderate-to-severe atopic dermatitis: integrated results from the phase 3 Measure Up 1 and Measure Up 2 studies","year":2024,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Calgary","funders":"","keywords":"Medicine; Eczema Area and Severity Index; Placebo; Atopic dermatitis; Dermatology Life Quality Index; Quality of life (healthcare); Randomized controlled trial; Severity of illness; Internal medicine; Dermatology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002175567,0.0004338564,0.001327096,0.0002810136,0.0003026988,0.00082819,0.0003403356,0.0005124608,0.002135324],"category_scores_gemma":[0.001488666,0.0002359983,0.002684208,0.000417244,0.0002677155,0.0005634301,0.0003991049,0.001204165,0.0002815875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005544123,"about_ca_system_score_gemma":0.0008016201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007803604,"about_ca_topic_score_gemma":0.002507703,"domain_scores_codex":[0.9990712,0.0004128826,0.0001033951,0.0001214573,0.0001613969,0.0001296554],"domain_scores_gemma":[0.9990447,0.0001650064,0.0003607334,0.00006754859,0.0001645036,0.0001975128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5633367,0.01788432,0.0898224,0.005129195,0.01795994,0.0002057476,0.0004412722,0.001276901,0.01618172,0.0002914712,0.005650205,0.28182],"study_design_scores_gemma":[0.2145563,0.3047704,0.4357062,0.001174459,0.01927161,0.0008602311,0.0004907002,0.001749739,0.009522666,0.0004756815,0.01128458,0.0001373277],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865462,0.008290122,0.0003372695,0.0001862038,0.00007059817,0.0009801114,0.002027382,0.00003418039,0.001527958],"genre_scores_gemma":[0.993777,0.002247877,0.0005834276,0.0003114865,0.00005380036,0.000886074,0.001628901,0.000006343111,0.0005050231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002175567,"threshold_uncertainty_score":0.01150566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017044620747292,"score_gpt":0.2930086273057454,"score_spread":0.2728381810982725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}