{"id":"W4401436130","doi":"10.1093/bjd/ljae266.102","title":"729 - A phase 2b, randomized, double-blinded, parallel-group, placebo-controlled, international, multicenter, study to evaluate the efficacy and safety of rezpegaldesleukin in adults with moderate-to-severe atopic dermatitis","year":2024,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Barrie Urology Group; Lynde Centre for Dermatology; University of Toronto; Queen's University","funders":"","keywords":"Medicine; Eczema Area and Severity Index; Atopic dermatitis; Placebo; Internal medicine; Randomized controlled trial; Body surface area; Adverse effect; Dosing; Gastroenterology; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003163298,0.00276974,0.003114052,0.0005027655,0.0007275739,0.001119021,0.001162255,0.002376632,0.01133837],"category_scores_gemma":[0.001477717,0.0009245437,0.001472585,0.0004053438,0.001429004,0.001256441,0.0003717895,0.003275546,0.001980974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008227191,"about_ca_system_score_gemma":0.00177756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005608951,"about_ca_topic_score_gemma":0.001458105,"domain_scores_codex":[0.9988838,0.0005445884,0.00007348446,0.0002305873,0.0001124951,0.0001550799],"domain_scores_gemma":[0.9991024,0.0001783946,0.0001917518,0.00007865246,0.00009227099,0.0003565993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9422132,0.03294983,0.0007775927,0.0006384635,0.0005697256,0.00004896297,0.00004068687,0.0001645044,0.008181823,0.0001189085,0.001364893,0.01293143],"study_design_scores_gemma":[0.8985385,0.09936475,0.0008042487,0.00001650695,0.0001464462,0.00002493003,0.000008830143,0.0001035903,0.000363959,0.00005134048,0.0005683802,0.000008528598],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553925,0.00710981,0.001736809,0.001178818,0.001121054,0.02557761,0.003408685,0.000293936,0.004180721],"genre_scores_gemma":[0.9536906,0.003392271,0.005297861,0.003549251,0.001263936,0.0237658,0.002653156,0.00006326412,0.006323794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01133837,"threshold_uncertainty_score":0.03793067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497239482065977,"score_gpt":0.3125974713425097,"score_spread":0.2976250765218499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}