{"id":"W4401438658","doi":"10.21203/rs.3.rs-4849400/v1","title":"Neoadjuvant cabozantinib restores CD8 T cells in patients with locally advanced non-metastatic clear cell renal cell carcinoma: a phase 2 trial","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Cabozantinib; Medicine; Renal cell carcinoma; CD8; Internal medicine; Oncology; Cancer research; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004974076,0.001215211,0.002075354,0.000245955,0.000331405,0.0009600235,0.0004905234,0.0008563416,0.003726471],"category_scores_gemma":[0.0005553897,0.0003655097,0.001113166,0.0002688063,0.0007123649,0.000637659,0.0002455054,0.002721854,0.0009626577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001125113,"about_ca_system_score_gemma":0.001172634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001975038,"about_ca_topic_score_gemma":0.005508788,"domain_scores_codex":[0.9998459,0.00005679416,0.000007186459,0.00002914632,0.00001374209,0.0000473664],"domain_scores_gemma":[0.9997163,0.00005695526,0.00003631715,0.00002628701,0.00001783498,0.0001461261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7878121,0.01379611,0.002860881,0.001150291,0.001577014,0.0002848473,0.0001977977,0.002808672,0.02985448,0.0004656673,0.008731402,0.1504607],"study_design_scores_gemma":[0.7494412,0.2221928,0.01060863,0.0001289289,0.001058444,0.000449515,0.0001320333,0.001616843,0.004603066,0.0005954771,0.009118062,0.00005495251],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874951,0.006122296,0.0003436256,0.001568683,0.0003640773,0.0005132952,0.0009066989,0.0001662617,0.002520054],"genre_scores_gemma":[0.9885156,0.003865008,0.0007482799,0.0009730878,0.0002240164,0.0006482225,0.001809399,0.00004558379,0.003170718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003726471,"threshold_uncertainty_score":0.01246631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03894837905595837,"score_gpt":0.3947979151561037,"score_spread":0.3558495361001453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}