{"id":"W4401438868","doi":"10.1016/j.jinf.2024.106237","title":"Replication, safety and immunogenicity of the vectored Ebola vaccine rVSV-ΔG-ZEBOV-GP in a sub-Saharan African paediatric population: A randomised controlled, open-label trial in children aged 1-12 years living in Lambaréné, Gabon","year":2024,"lang":"en","type":"article","venue":"Journal of Infection","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Innovative Medicines Initiative; Göteborgs Universitet; European and Developing Countries Clinical Trials Partnership; Innovative Health Initiative","keywords":"Ebola vaccine; Immunogenicity; Medicine; Virology; Adverse effect; Immunosuppression; Vaccination; Population; Immunology; Ebola virus; Immune system; Internal medicine; Virus; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002110695,0.001596038,0.002594712,0.0004770403,0.0003987096,0.000951677,0.0007670365,0.001604028,0.003923703],"category_scores_gemma":[0.001816682,0.0006704684,0.001512973,0.0004741254,0.001189617,0.0008699686,0.0004706956,0.002020121,0.00043476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008373525,"about_ca_system_score_gemma":0.00103969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001169343,"about_ca_topic_score_gemma":0.001604018,"domain_scores_codex":[0.9992058,0.0004175496,0.00006224785,0.0001160705,0.00006467199,0.0001336324],"domain_scores_gemma":[0.9991539,0.0002229285,0.0002743744,0.00005827067,0.00006559281,0.0002249104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9356485,0.02481727,0.00392859,0.002375754,0.001240285,0.0001750921,0.0003567232,0.0003811706,0.007277166,0.0001023059,0.0003835156,0.02331359],"study_design_scores_gemma":[0.6224732,0.3607837,0.01279852,0.0001610614,0.001002349,0.000120332,0.0001746079,0.0002503772,0.001079704,0.0001120958,0.001018825,0.00002526286],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948241,0.002752672,0.0001268586,0.0001181769,0.00009505993,0.001622874,0.0001948272,0.00001402669,0.0002514221],"genre_scores_gemma":[0.9895675,0.003299176,0.0007301506,0.0002221741,0.0001939224,0.00460294,0.0003049038,0.000008916822,0.001070342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003923703,"threshold_uncertainty_score":0.01312613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715981954009103,"score_gpt":0.3117549227737018,"score_spread":0.2945951032336108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}