{"id":"W4401441587","doi":"10.1126/sciadv.adp6182","title":"Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Steno Diabetes Center Aarhus; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Région Hauts-de-France; Novo Nordisk Fonden; Agence Nationale de la Recherche; Ligue Contre le Cancer; KU Leuven; Université de Lille","keywords":"Mesenchymal stem cell; Cell biology; Calcium; Calcium signaling; RNA-Seq; Cell; RNA; Chemistry; Biology; Signal transduction; Biochemistry; Gene expression; Gene; Transcriptome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002196514,0.0001726731,0.0002733618,0.0002626221,0.0002667265,0.0005205004,0.0001987218,0.0003135904,0.0007059866],"category_scores_gemma":[0.0001688623,0.0001255689,0.0002618411,0.0001983576,0.000207317,0.0001397517,0.0002037863,0.0004466569,0.0002912806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251499,"about_ca_system_score_gemma":0.0002735589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001256064,"about_ca_topic_score_gemma":0.003037899,"domain_scores_codex":[0.9998364,0.00000953596,0.000007572245,0.0000744152,0.00004681408,0.00002507855],"domain_scores_gemma":[0.9998901,0.00003024283,0.0000245581,0.00001056238,0.00002572979,0.00001885166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006897718,0.000009771734,0.001647367,0.00003978764,0.0000114692,0.00004192785,0.00002924619,0.0003623824,0.9946945,0.0001779021,0.0001808339,0.002735664],"study_design_scores_gemma":[0.00002524404,0.0001530121,0.08233053,0.0000250901,0.0001010169,0.0003798424,0.0002052624,0.03586549,0.8703604,0.0006524319,0.009861867,0.00003982003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9488407,0.001384924,0.03786423,0.0002006149,0.0001003243,0.00004459383,0.008115492,0.0006244844,0.002824558],"genre_scores_gemma":[0.9595141,0.0007632077,0.0298909,0.0002596342,0.00002231574,0.00008518442,0.006689827,0.0001876997,0.002587088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256064,"threshold_uncertainty_score":0.002497494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732831953741095,"score_gpt":0.3139642257916156,"score_spread":0.2966359062542047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}