{"id":"W4401450637","doi":"10.1200/jco.23.02238","title":"Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Moonshot Research and Development Program; School of Medicine, University of North Carolina at Chapel Hill; National Cancer Institute; National Institutes of Health; Broad Institute; American Lebanese Syrian Associated Charities; St. Baldrick's Foundation; Children's Hospital of Philadelphia; Nationwide Children's Hospital; Cancer Moonshot; Seattle Children's Research Institute","keywords":"Medicine; Lymphoblastic Leukemia; Leukemia; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007818301,0.000261504,0.0002130949,0.0005397088,0.0002454844,0.0004482327,0.000203324,0.0002517987,0.0008268448],"category_scores_gemma":[0.002498882,0.00009132307,0.0002049561,0.0006895501,0.000435932,0.0002317567,0.0004525738,0.0004740405,0.0001215254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002772482,"about_ca_system_score_gemma":0.000207768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133532,"about_ca_topic_score_gemma":0.0010617,"domain_scores_codex":[0.9994721,0.0002077688,0.00003119828,0.0001277207,0.00008153158,0.00007968287],"domain_scores_gemma":[0.9984605,0.0003403074,0.0008672152,0.00008926213,0.00005858438,0.0001841192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003074356,0.0000223692,0.9936318,0.00001560535,0.0000735212,0.00009710872,0.00003793567,0.000134474,0.001221469,0.00007715699,0.0001053188,0.004275894],"study_design_scores_gemma":[0.00001083971,0.00009882173,0.9983009,0.000006353417,0.0000460713,0.0003924892,0.0000639592,0.0002544725,0.0003129143,0.0002590104,0.0002518421,0.00000249285],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984083,0.0007639468,0.0001927248,0.000122654,0.000005125275,0.00000376999,0.0002243378,0.000006483844,0.0002727377],"genre_scores_gemma":[0.9994826,0.0001703359,0.00009324342,0.00002908809,0.00000949382,0.000004042958,0.0001718224,0.000002622351,0.00003659124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133532,"threshold_uncertainty_score":0.004134774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.103847093689553,"score_gpt":0.4783862440527168,"score_spread":0.3745391503631638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}