{"id":"W4401455963","doi":"10.3390/vaccines12080902","title":"Intranasal Delivery of Quillaja brasiliensis Saponin-Based Nanoadjuvants Improve Humoral Immune Response of Influenza Vaccine in Aged Mice","year":2024,"lang":"en","type":"article","venue":"Vaccines","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Sanofi Pasteur; Comisión Sectorial de Investigación Científica; Canada First Research Excellence Fund; Sanofi","keywords":"Saponin; Nasal administration; Immune system; Influenza vaccine; Immunology; Medicine; Humoral immunity; Virology; Vaccination; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006802776,0.0002763233,0.0001584802,0.0001698949,0.00006206985,0.0001136512,0.00009677179,0.0001611122,0.0004824619],"category_scores_gemma":[0.00003979764,0.00006869622,0.0001348536,0.00004770657,0.0001067979,0.0001564162,0.00007084969,0.0002651375,0.0001022659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001416795,"about_ca_system_score_gemma":0.00009937905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007587958,"about_ca_topic_score_gemma":0.001377815,"domain_scores_codex":[0.9999658,0.000003682724,0.000002497985,0.000008940893,0.000008062686,0.00001103614],"domain_scores_gemma":[0.999972,0.000002337305,0.000009490951,0.000001988706,0.00000440976,0.000009695547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008935751,0.00003232089,0.00005338626,0.00003019504,0.000002183253,0.00001175183,0.000004875333,0.00003929082,0.9984899,0.00002393922,0.00001915402,0.001203765],"study_design_scores_gemma":[0.00002428099,0.001013586,0.00302501,0.000008197864,0.00001997212,0.0000614651,0.00001375921,0.0008254533,0.993242,0.0000357185,0.001726324,0.000004229858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933808,0.00215119,0.003078796,0.00007297509,0.00005697084,0.00004138203,0.0002108968,0.00007627169,0.0009306888],"genre_scores_gemma":[0.9951984,0.000927239,0.001959792,0.00005215657,0.00001358431,0.00003002676,0.0001632786,0.00001041908,0.001645028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007587958,"threshold_uncertainty_score":0.001614034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360608052623992,"score_gpt":0.2938266673916172,"score_spread":0.2802205868653773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}