{"id":"W4401461538","doi":"10.1080/10408363.2024.2358304","title":"G protein-coupled receptor (GPCR) pharmacogenomics","year":2024,"lang":"en","type":"review","venue":"Critical Reviews in Clinical Laboratory Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"Danmarks Frie Forskningsfond; Lundbeckfonden","keywords":"Pharmacogenomics; G protein-coupled receptor; Computational biology; Receptor; Chemistry; Pharmacology; Bioinformatics; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.009386857,0.0006416022,0.002372654,0.0001506307,0.000153855,0.0002165123,0.001194807,0.0008377846,0.000434009],"category_scores_gemma":[0.007809256,0.0004412368,0.001068934,0.001033162,0.00103611,0.00001565332,0.0003922231,0.001079659,0.0009758621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005273552,"about_ca_system_score_gemma":0.001428917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001592823,"about_ca_topic_score_gemma":0.000003593811,"domain_scores_codex":[0.9931002,0.001407113,0.00277419,0.001673657,0.0003669996,0.0006778327],"domain_scores_gemma":[0.9981394,0.0004224848,0.0003334976,0.0005911476,0.0001400582,0.0003733624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000144204,0.0002681535,0.000005362072,0.01938811,0.00008623806,0.00003621231,0.000008550988,4.572137e-7,0.002350274,0.006569118,0.008137986,0.9631351],"study_design_scores_gemma":[0.00008673719,0.0003009827,6.448322e-8,0.01168869,0.0002686505,0.000003940629,0.000008264194,0.00001891493,0.0001282598,0.0002813401,0.9866722,0.0005419428],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001253392,0.9953696,0.000127247,0.00008820512,0.002482509,0.00138343,0.0001201908,0.00002505485,0.0002783989],"genre_scores_gemma":[0.00002100839,0.9934015,0.003748785,0.0004518335,0.00162636,0.0003894395,0.00005591015,0.00006563785,0.0002395686],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9785342,"threshold_uncertainty_score":0.999804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1598699836379723,"score_gpt":0.4937108269780289,"score_spread":0.3338408433400566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}