{"id":"W4401470131","doi":"10.1111/acel.14301","title":"A defective splicing machinery promotes senescence through MDM4 alternative splicing","year":2024,"lang":"en","type":"article","venue":"Aging Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Spliceosome; RNA splicing; Senescence; Biology; Alternative splicing; Cell biology; Telomere; Genetics; Gene; Exon; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002705224,0.0002066011,0.0001485233,0.00006650527,0.000145148,0.0001295763,0.0002174202,0.00007849247,0.0000139722],"category_scores_gemma":[0.00005701004,0.0001821508,0.0001164491,0.000191384,0.00006361042,0.0000177102,0.0002013946,0.0002643814,0.00005819196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004374992,"about_ca_system_score_gemma":0.00008659682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007745273,"about_ca_topic_score_gemma":0.00005085937,"domain_scores_codex":[0.9985164,0.00007490054,0.0001684572,0.0005830903,0.0001980696,0.0004591169],"domain_scores_gemma":[0.9994616,0.00005712784,0.00003883073,0.0002959305,0.00005834541,0.0000881517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001608451,0.00002581322,0.001851661,0.000135309,0.00005343165,0.00007733126,0.0005307083,0.0001627963,0.9935493,0.0001700583,0.0004436736,0.002983872],"study_design_scores_gemma":[0.0002363274,0.0001658614,0.0003420458,0.0002405659,0.00002119059,0.0000489732,0.0002132487,0.00930652,0.9854686,0.0004191443,0.003249022,0.0002885001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676185,0.002873978,0.02237799,0.0001978783,0.0002127932,0.0002335352,0.000008112192,0.00006783339,0.006409381],"genre_scores_gemma":[0.9939516,0.0002592712,0.001234054,0.0002205171,0.0004622221,0.00002034091,0.0000289949,0.00004744218,0.003775591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02633307,"threshold_uncertainty_score":0.7427893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151032681102024,"score_gpt":0.2875093860887315,"score_spread":0.2759990592777113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}