{"id":"W4401470131","doi":"10.1111/acel.14301","title":"A defective splicing machinery promotes senescence through MDM4 alternative splicing","year":2024,"lang":"en","type":"article","venue":"Aging Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Spliceosome; RNA splicing; Senescence; Biology; Alternative splicing; Cell biology; Telomere; Genetics; Gene; Exon; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119005,0.0002364812,0.0001819541,0.000284895,0.0001313314,0.0002445425,0.0001356026,0.0002237959,0.0008905432],"category_scores_gemma":[0.0001590785,0.0001203314,0.0002464066,0.0001299804,0.0002033323,0.0001698032,0.0001761024,0.0002703869,0.000308224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374051,"about_ca_system_score_gemma":0.000107693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000119203,"about_ca_topic_score_gemma":0.0001644957,"domain_scores_codex":[0.9998918,0.00002615218,0.00001739916,0.0000265852,0.00002121539,0.0000168603],"domain_scores_gemma":[0.9998608,0.00002717067,0.00004771308,0.00002352482,0.00001318052,0.0000276204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004747997,0.0000101912,0.0005014957,0.000009181425,0.000003786367,0.00008685478,0.000004843844,0.00001733893,0.9984607,0.0000876074,0.00001477383,0.0007557388],"study_design_scores_gemma":[0.00000900585,0.0002460835,0.007151016,0.000003491376,0.00001423035,0.0009964936,0.00001788365,0.0005982541,0.9885981,0.0001738691,0.002188053,0.000003483493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958033,0.000992366,0.002299304,0.00006968381,0.00001647453,0.000006256727,0.00009767064,0.00006862401,0.0006463203],"genre_scores_gemma":[0.9974735,0.0004454491,0.00108143,0.00003097133,0.000008978116,0.000006477706,0.0001806198,0.0000109621,0.0007614627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008905432,"threshold_uncertainty_score":0.002979219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151032681102024,"score_gpt":0.2875093860887315,"score_spread":0.2759990592777113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}