{"id":"W4401486093","doi":"10.1016/j.fct.2024.114916","title":"Human next-generation risk assessment of trichothecene toxicity","year":2024,"lang":"en","type":"article","venue":"Food and Chemical Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Alliance Nationale pour les Sciences de la Vie et de la Santé","keywords":"Trichothecene; Genotoxicity; DNA damage; Pharmacology; In vivo; Diacetoxyscirpenol; Toxicity; Comet assay; Carcinogen; Toxicology; Potency; Biology; Mycotoxin; Chemistry; In vitro; Medicine; DNA; Biochemistry; Genetics; Internal medicine; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670887,0.0001369172,0.0001915718,0.000045181,0.00005966344,0.00003340242,0.00008952055,0.0002205478,0.0000585708],"category_scores_gemma":[0.00002062167,0.0001249868,0.000100045,0.00008572865,0.0001003872,0.000004812526,0.00009753006,0.0001352669,0.000001030018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002198339,"about_ca_system_score_gemma":0.00005853102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005222741,"about_ca_topic_score_gemma":0.00002131183,"domain_scores_codex":[0.9990488,0.0000598859,0.0002369215,0.0003685342,0.00009965851,0.000186203],"domain_scores_gemma":[0.9996255,0.00001575723,0.00005633146,0.0001834925,0.00004051006,0.00007837513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008639739,0.0001092091,0.0005745646,0.00003827599,0.00009701558,0.000001595769,0.00001808466,0.000009502923,0.9927785,0.001206827,0.0007400159,0.0044177],"study_design_scores_gemma":[0.0003286723,0.00107879,0.001736321,0.000008241656,0.00005008694,0.00001632438,0.00002194468,0.0009913928,0.9906051,0.0002875363,0.004721218,0.0001544257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958903,0.001286459,0.001303468,0.0001639499,0.0001426231,0.0001446959,0.00007268209,0.00001623126,0.0009795802],"genre_scores_gemma":[0.9981593,0.0002644778,0.0007752617,0.0001304123,0.0004056113,0.00002612015,0.0001002455,0.00001534375,0.0001231924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004263274,"threshold_uncertainty_score":0.5096813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02880718543533408,"score_gpt":0.3046473573375009,"score_spread":0.2758401719021668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}