{"id":"W4401487949","doi":"10.1038/s41467-024-51315-8","title":"A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Peptide vaccine; Oncology; Adverse effect; Immune system; Glioblastoma; Immunotherapy; Antigen; Immunology; Cancer research; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361958,0.0001861101,0.0002616117,0.0002763891,0.0002207411,0.00002248674,0.0005116531,0.0002166929,0.0001859089],"category_scores_gemma":[0.00003769007,0.000126159,0.00007226296,0.0008803064,0.0002305587,0.0001732729,0.00007311459,0.000718153,0.00003579268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006230082,"about_ca_system_score_gemma":0.0001198253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001854523,"about_ca_topic_score_gemma":0.001065772,"domain_scores_codex":[0.9990117,0.0002846874,0.000264042,0.0001959153,0.00005970526,0.0001839685],"domain_scores_gemma":[0.9980652,0.0004521256,0.0001246057,0.001056342,0.0002899967,0.00001173529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04370126,0.003803226,0.5005022,0.0003590254,0.007682572,0.00001346362,0.009021598,0.00001956611,0.320529,0.06354414,0.0316224,0.01920159],"study_design_scores_gemma":[0.004026212,0.001173111,0.6405752,0.0005227134,0.0002639593,0.00001586487,0.0002356828,0.00002576704,0.01910216,0.00003017412,0.3336979,0.0003312931],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767492,0.02000176,0.00003055271,0.001110574,0.00008107083,0.0004412555,0.0001060101,0.0001842673,0.001295343],"genre_scores_gemma":[0.9914464,0.0007846419,0.0008509342,0.00008799101,0.000005842595,0.00005574536,0.0007571748,0.00003378621,0.005977513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3020755,"threshold_uncertainty_score":0.5144614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190274580385199,"score_gpt":0.2660266643130756,"score_spread":0.2541239185092237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}