{"id":"W4401496660","doi":"10.1101/2024.08.10.607446","title":"H3K36 Methylation - a Guardian of Epigenome Integrity","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"","keywords":"Epigenome; Biology; Epigenetics; Methyltransferase; Cell biology; Enhancer; Euchromatin; Epigenomics; Genetics; DNA methylation; Chromatin; Heterochromatin; Methylation; Gene; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298269,0.000209475,0.0002100334,0.000240594,0.0002065808,0.0003858143,0.0002577438,0.0002593985,0.001309152],"category_scores_gemma":[0.00008158838,0.0001683571,0.0002247675,0.0001789336,0.0004334649,0.0002524473,0.0004491919,0.0004406758,0.0003484574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00024829,"about_ca_system_score_gemma":0.0002221792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007503747,"about_ca_topic_score_gemma":0.0008135674,"domain_scores_codex":[0.9998767,0.00001245023,0.000009948729,0.00003694012,0.00004020721,0.00002382514],"domain_scores_gemma":[0.999895,0.00001046069,0.00002766703,0.00002690729,0.00001284192,0.00002711101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000506458,0.000001995526,0.0004902933,0.00001324822,0.00000344439,0.00001390647,0.000007141362,0.00002755587,0.9987271,0.00009799236,0.000009329747,0.0005574363],"study_design_scores_gemma":[0.000004929685,0.00006057377,0.01530467,0.000004255243,0.00001210105,0.0002207117,0.00003062539,0.0004468328,0.9819736,0.0002340679,0.001703433,0.00000423079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822356,0.002757164,0.01164754,0.0001491894,0.00003209359,0.00001429195,0.0008600859,0.0001747684,0.002129281],"genre_scores_gemma":[0.9952424,0.0004893276,0.002194327,0.00003882714,0.000004840781,0.000008252418,0.0002768965,0.00001833549,0.001726792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309152,"threshold_uncertainty_score":0.00437957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572751281307107,"score_gpt":0.2503428339833775,"score_spread":0.2346153211703064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}