{"id":"W4401499711","doi":"10.1093/cvr/cvae169","title":"PITX2 deficiency leads to atrial mitochondrial dysfunction","year":2024,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Hartstichting; ZonMw; Fondation Leducq; University of Birmingham; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Deutsches Zentrum für Herz-Kreislaufforschung; European Commission; University of Oxford; National Institute for Health and Care Research; Deutsche Forschungsgemeinschaft; UK Research and Innovation; Wellcome Trust; British Heart Foundation; Department of Health and Social Care","keywords":"Cardiology; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304234,0.0005656527,0.0002334742,0.0002733133,0.0001977389,0.0001811063,0.0001797823,0.0003845035,0.002350431],"category_scores_gemma":[0.0002124431,0.000104313,0.0002267012,0.0001775634,0.0002750139,0.0001159389,0.0003486932,0.0003185645,0.0002878329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187255,"about_ca_system_score_gemma":0.0001090774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000220728,"about_ca_topic_score_gemma":0.0002841103,"domain_scores_codex":[0.9999013,0.00001550864,0.00001697812,0.00003028242,0.00002270761,0.00001317263],"domain_scores_gemma":[0.9998416,0.00003387376,0.00005909453,0.00001061483,0.00000879584,0.00004601466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001062539,0.0000727124,0.008167883,0.000153434,0.00005942842,0.004400143,0.00006029875,0.0001909489,0.979571,0.0001587812,0.0002772447,0.005825553],"study_design_scores_gemma":[0.0004125679,0.002072336,0.2540848,0.0001001901,0.0004191636,0.07351332,0.0003324599,0.004503851,0.6547525,0.0006386287,0.009133599,0.00003657232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968804,0.0007968484,0.001294507,0.00009900746,0.00002639621,0.00001849603,0.0004276284,0.00005488269,0.0004018395],"genre_scores_gemma":[0.9975575,0.0004567889,0.000668733,0.0000563037,0.00001829375,0.00002694573,0.0005574566,0.00001515307,0.0006427736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002350431,"threshold_uncertainty_score":0.007862926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04324791993168949,"score_gpt":0.3550772653438253,"score_spread":0.3118293454121358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}