{"id":"W4401504256","doi":"10.1182/blood.2024025603","title":"Unbalanced MYC break-apart FISH patterns indicate the presence of a MYC rearrangement in HGBCL-DH-BCL2","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; BC Cancer Agency; Spinal Cord Injury BC; University of British Columbia","funders":"National Cancer Institute","keywords":"Biology; Gene rearrangement; Fluorescence in situ hybridization; Context (archaeology); Fish ; Immunohistochemistry; Lymphoma; Gene; Molecular biology; Chromosome; Cancer research; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003471096,0.0002102031,0.000153049,0.00106049,0.000168497,0.0002853511,0.0001660801,0.0003259071,0.003672505],"category_scores_gemma":[0.0008514703,0.0001340657,0.00008112406,0.0004340722,0.000425608,0.0002338498,0.0003504513,0.0001933079,0.0005335634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548715,"about_ca_system_score_gemma":0.0001173066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625743,"about_ca_topic_score_gemma":0.001574829,"domain_scores_codex":[0.9997932,0.00002344996,0.00002643396,0.00003690992,0.00006020109,0.00005972525],"domain_scores_gemma":[0.9995924,0.0001280946,0.0001033356,0.00003182973,0.00005917335,0.00008520199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000561314,0.00003124043,0.8326605,0.00005238507,0.00002860474,0.001688169,0.0001962565,0.0001004503,0.1595038,0.00007136854,0.0002063261,0.004899595],"study_design_scores_gemma":[0.00003070765,0.0002069011,0.9603782,0.000008444506,0.00005088946,0.01208863,0.0003838811,0.0005835877,0.0253023,0.0001412916,0.0008205157,0.00000462221],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986655,0.0001251127,0.0003532774,0.00002308254,0.000002035446,0.000007302876,0.0001005966,0.00001510375,0.000708156],"genre_scores_gemma":[0.9995366,0.00004262472,0.000198744,0.00001685412,0.00000247674,0.000003001406,0.0001203586,0.000003623195,0.00007568672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003672505,"threshold_uncertainty_score":0.01228577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100739069201859,"score_gpt":0.2491625980920748,"score_spread":0.2381552074000562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}