{"id":"W4401507578","doi":"10.1016/j.ccell.2024.07.011","title":"Leading medulloblastoma to a differentiation end","year":2024,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Medulloblastoma; Psychological repression; EZH2; Cancer research; Differentiation therapy; Cellular differentiation; Biology; Genetics; Cell culture; Histone; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00001948383,0.00007379139,0.0001030149,0.0000500363,0.00002115107,0.00002732522,0.00002126279,0.00002547754,0.00126343],"category_scores_gemma":[0.000003590212,0.0000567827,0.00005229181,0.0001118725,0.000005872553,0.00003217546,0.00001259622,0.00003817765,0.0003885895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296039,"about_ca_system_score_gemma":0.00003962022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001317648,"about_ca_topic_score_gemma":0.0001225067,"domain_scores_codex":[0.99952,0.000004811941,0.00007445338,0.0001710005,0.000106162,0.0001235548],"domain_scores_gemma":[0.9997548,0.00002068754,0.000008518236,0.0000961142,0.00001740639,0.0001024626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001465287,0.0007332909,0.04536198,0.001174071,0.0004801294,0.0007784948,0.005120794,0.0001515887,0.5586897,0.001629554,0.121675,0.2640589],"study_design_scores_gemma":[0.001344169,0.0004388165,0.04849218,0.0009148122,0.0004988194,0.00001997202,0.0001967398,0.001543998,0.7322566,0.00008768826,0.2139578,0.0002483841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818605,0.006859666,0.0001527767,0.001826719,0.0005855464,0.0002142751,0.00001159453,0.00008125799,0.0084077],"genre_scores_gemma":[0.9969274,0.0001943595,0.0001231033,0.0003291959,0.0002076855,0.0001307321,0.00001024201,0.00001594777,0.002061302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2638105,"threshold_uncertainty_score":0.9996495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480022069946773,"score_gpt":0.2927522654219445,"score_spread":0.2779520447224768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}