{"id":"W4401507578","doi":"10.1016/j.ccell.2024.07.011","title":"Leading medulloblastoma to a differentiation end","year":2024,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Medulloblastoma; Psychological repression; EZH2; Cancer research; Differentiation therapy; Cellular differentiation; Biology; Genetics; Cell culture; Histone; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006769752,0.0002747073,0.0003489922,0.0007296056,0.001581983,0.002606492,0.0004561776,0.001796318,0.007011627],"category_scores_gemma":[0.00201475,0.0002385228,0.0004406924,0.0004152657,0.00155532,0.002606689,0.002638345,0.004659376,0.003263712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002583756,"about_ca_system_score_gemma":0.003959317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004782661,"about_ca_topic_score_gemma":0.01152282,"domain_scores_codex":[0.9995158,0.00005818519,0.00004550961,0.000056956,0.0001472967,0.0001762482],"domain_scores_gemma":[0.9990195,0.0001621536,0.0001031713,0.00007880721,0.0002427282,0.0003936338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001262039,0.0002343382,0.02371676,0.0005482282,0.0001459464,0.02460013,0.002059866,0.001818819,0.03803158,0.4406992,0.1866764,0.2802068],"study_design_scores_gemma":[0.0001067659,0.0004320225,0.007173001,0.0004027173,0.0000881006,0.01586051,0.001824745,0.001182085,0.03557662,0.134821,0.8024805,0.00005187991],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2540885,0.08693925,0.04574069,0.3283767,0.01767769,0.0003576579,0.001800017,0.001919746,0.2630998],"genre_scores_gemma":[0.8272792,0.02609836,0.01854645,0.04895648,0.003919285,0.00008783158,0.0009475087,0.000444479,0.07372037],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007011627,"threshold_uncertainty_score":0.02345622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480022069946773,"score_gpt":0.2927522654219445,"score_spread":0.2779520447224768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}