{"id":"W4401510369","doi":"10.1101/cshperspect.a041593","title":"The Role of B Lymphocytes in Type 1 Diabetes","year":2024,"lang":"en","type":"article","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Pathogenesis; Immunology; Autoantibody; Bone marrow; Disease; Peripheral tolerance; Biology; Autoimmunity; Type 1 diabetes; Central tolerance; Self Tolerance; Antigen; Medicine; Immune tolerance; Diabetes mellitus; Antibody; Pathology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083049,0.00008728521,0.0001309458,0.00007230423,0.00002438686,0.0000107298,0.000143217,0.0000580275,0.000009234884],"category_scores_gemma":[0.0003551638,0.00006350256,0.00003187285,0.0002637592,0.0001627264,0.000003078038,0.00004800233,0.0000887731,0.000002070746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005175209,"about_ca_system_score_gemma":0.00006146292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006858469,"about_ca_topic_score_gemma":0.00005627551,"domain_scores_codex":[0.9993218,0.00003332948,0.0001518909,0.0002048172,0.00009283794,0.0001953849],"domain_scores_gemma":[0.9996818,0.00006712673,0.00002736767,0.0001593062,0.00004039316,0.00002396185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003281631,0.00006879579,0.06421099,0.00003867213,0.00009000547,0.000003942969,0.0007335898,0.00005195422,0.9053647,0.02697608,0.0002251045,0.002203359],"study_design_scores_gemma":[0.003238861,0.001374338,0.3126562,0.001853296,0.00008677735,3.367428e-7,0.02344048,0.004898204,0.442804,0.002693102,0.2061802,0.000774183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.819524,0.178397,0.000002124717,0.0003531115,0.0001527267,0.00008179586,0.000001322477,0.000008739233,0.001479136],"genre_scores_gemma":[0.9946438,0.005098314,0.00002175356,0.00003091137,0.0001114948,0.00001231066,8.368378e-7,0.00001418816,0.00006640001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4625607,"threshold_uncertainty_score":0.2589559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004938096629839694,"score_gpt":0.240924320974986,"score_spread":0.2359862243451464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}