{"id":"W4401511976","doi":"10.1101/2024.08.12.607550","title":"Exploring adaptive introgression in modern human circadian rhythm genes","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; SickKids Foundation; The Scarborough Hospital; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; Introgression; Chronotype; Haplotype; Evolutionary biology; Genetics; Cline (biology); Balancing selection; International HapMap Project; Allele; 1000 Genomes Project; Circadian rhythm; Gene; Genotype; Population; Single-nucleotide polymorphism; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002808523,0.0002013928,0.0002261662,0.0006766949,0.0003032309,0.0003408072,0.0001420102,0.0002230577,0.001565941],"category_scores_gemma":[0.0006227259,0.000111372,0.0002733813,0.0007081439,0.0002737629,0.000119276,0.000405772,0.0003369465,0.000103269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234946,"about_ca_system_score_gemma":0.00007388844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177075,"about_ca_topic_score_gemma":0.001663459,"domain_scores_codex":[0.9998112,0.00004237684,0.00001399224,0.00007566363,0.00003141101,0.00002531223],"domain_scores_gemma":[0.9996493,0.0001248727,0.00009970432,0.00004708841,0.00003197411,0.00004704918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009228577,0.00007975504,0.7548617,0.0001226159,0.000625279,0.0008007538,0.00149206,0.0009749837,0.2158519,0.0005443043,0.0002108414,0.02351298],"study_design_scores_gemma":[0.00002181808,0.0001461276,0.9930033,0.00001185564,0.00007654403,0.0007686979,0.0002488285,0.0007132991,0.003899067,0.0002025141,0.0008984876,0.000009444208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991185,0.00009235294,0.0004671152,0.00001172472,0.000002221409,0.000003254115,0.0001198783,0.000003719095,0.0001812601],"genre_scores_gemma":[0.9991067,0.00005074198,0.0004507655,0.00001355182,0.000004135715,0.000003240314,0.0002268533,0.000003428942,0.0001405635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001565941,"threshold_uncertainty_score":0.005238593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04369246486736417,"score_gpt":0.2585033807045983,"score_spread":0.2148109158372341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}