{"id":"W4401512331","doi":"10.1136/gutjnl-2024-iddf.187","title":"IDDF2024-ABS-0195 Long-term efficacy of tenofovir alafenamide in HBeAg-positive and -negative chronic hepatitis B patients treated for up to 8 years in 2 phase 3 studies","year":2024,"lang":"en","type":"article","venue":"","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Liver Centre; University Health Network","funders":"","keywords":"Medicine; Tenofovir alafenamide; Discontinuation; Internal medicine; Viremia; Gastroenterology; Emtricitabine; Hepatitis B; Intention-to-treat analysis; HBeAg; Randomized controlled trial; Chronic hepatitis; Viral load; Hepatitis B virus; Immunology; Antibody; Lamivudine; HBsAg; Human immunodeficiency virus (HIV); Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003174153,0.0007876539,0.001514666,0.0003358278,0.0003804659,0.0009037817,0.0006492374,0.001293284,0.004534482],"category_scores_gemma":[0.0008905513,0.0003186068,0.001425731,0.0002708608,0.0004613081,0.0004303138,0.0003270632,0.001777298,0.001104964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004351464,"about_ca_system_score_gemma":0.001076899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008803554,"about_ca_topic_score_gemma":0.002510903,"domain_scores_codex":[0.9991979,0.0004727965,0.00007924729,0.0000625696,0.00008258634,0.0001050429],"domain_scores_gemma":[0.9992484,0.0001583552,0.0001813236,0.00006486018,0.00009211689,0.0002549301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7039834,0.02479772,0.007439744,0.001474244,0.003376266,0.0002472531,0.0001573715,0.0007328657,0.0389392,0.0003129138,0.008188477,0.2103506],"study_design_scores_gemma":[0.699353,0.2598322,0.02544113,0.0002083776,0.001093827,0.000275638,0.00006432353,0.0006898565,0.003577069,0.0001832756,0.009240848,0.00004060096],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720352,0.01134649,0.0009372942,0.001366954,0.0005250872,0.00361672,0.003854113,0.0002240403,0.006094183],"genre_scores_gemma":[0.9763792,0.004755246,0.002395713,0.002511596,0.0004805954,0.003349489,0.004576395,0.00004531919,0.005506479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004534482,"threshold_uncertainty_score":0.01678675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0271549410238616,"score_gpt":0.3587109871936247,"score_spread":0.3315560461697631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}