{"id":"W4401514101","doi":"10.1016/j.cell.2024.07.030","title":"Macrophage-mediated myelin recycling fuels brain cancer malignancy","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"H2020 European Research Council; European Research Council; Aard- en Levenswetenschappen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek; KWF Kankerbestrijding; Oncode Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Genomics Centre","keywords":"Biology; Tumor microenvironment; Crosstalk; Cancer research; Myelin; Immune system; Macrophage; Microvesicles; Microglia; Mesenchymal stem cell; Glioblastoma; Phenotype; Immunology; Neuroscience; Cell biology; Genetics; Gene; Central nervous system; Inflammation; microRNA; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001605524,0.0001926093,0.000195091,0.0003911477,0.0002426096,0.0005269603,0.000118118,0.0002174542,0.0005244883],"category_scores_gemma":[0.0001681298,0.00007485879,0.0001230206,0.0002078282,0.0002700955,0.0003048841,0.0005557895,0.0003604077,0.0002284705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003845107,"about_ca_system_score_gemma":0.0004729229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006958523,"about_ca_topic_score_gemma":0.001962975,"domain_scores_codex":[0.9999069,0.00001615243,0.000004183849,0.0000130431,0.00002138076,0.00003840262],"domain_scores_gemma":[0.9999442,0.000004876431,0.000018313,0.000005280298,0.00001176393,0.00001544654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004403702,0.00004903573,0.0106308,0.0001822137,0.00002423395,0.0004289006,0.0001989735,0.0006641895,0.9576007,0.003611902,0.0007866306,0.02538203],"study_design_scores_gemma":[0.00004240763,0.0007222272,0.06608467,0.0001392033,0.0001011088,0.001922281,0.001669034,0.007008048,0.8623168,0.009211325,0.05073932,0.00004349859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845846,0.006354874,0.004791398,0.0006502928,0.00003903672,0.0000233619,0.0002788811,0.00009612484,0.003181286],"genre_scores_gemma":[0.9939284,0.003105423,0.00162875,0.0001472612,0.00001708313,0.00001725032,0.0001124685,0.00001113813,0.00103208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006958523,"threshold_uncertainty_score":0.002789855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147685798129982,"score_gpt":0.2622453066664084,"score_spread":0.2507684486851086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}