{"id":"W4401517042","doi":"10.1002/mds.29960","title":"Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa‐Induced Dyskinesia","year":2024,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health; Idorsia Pharmaceuticals; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Wellcome Trust; McGill University; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dyskinesia; Levodopa; Odds ratio; LRRK2; Parkinson's disease; Internal medicine; Quartile; Hazard ratio; Medicine; Dopaminergic; Genome-wide association study; Confidence interval; Oncology; Single-nucleotide polymorphism; Disease; Genotype; Dopamine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001819,0.0003491969,0.0003669675,0.0001691944,0.0001543703,0.00008889111,0.00006577805,0.00009534636,0.0001594086],"category_scores_gemma":[0.00006120014,0.0002595992,0.00009376869,0.00034671,0.00004460128,0.0001263738,0.00004613441,0.0001871465,0.00003227371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574521,"about_ca_system_score_gemma":0.00009585145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002205275,"about_ca_topic_score_gemma":0.0003843371,"domain_scores_codex":[0.9982491,0.00006340318,0.0002188772,0.0006220448,0.0004273138,0.0004192658],"domain_scores_gemma":[0.9992471,0.00005990425,0.0001100298,0.0002893663,0.00004542167,0.0002482095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008751681,0.003450603,0.8630451,0.0004853408,0.004526809,0.002723143,0.0006571241,0.00002153777,0.004037018,0.001621935,0.003497187,0.1150591],"study_design_scores_gemma":[0.0054034,0.001101981,0.9733235,0.0006454289,0.000787893,0.000003614438,0.0004774609,0.001777524,0.0008506082,0.004518435,0.01065831,0.0004519006],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934451,0.001790355,0.0003604893,0.001281706,0.0001944526,0.0007206579,0.0001884833,0.0002576,0.001761138],"genre_scores_gemma":[0.9971792,0.0005005908,0.0001243679,0.000811163,0.00004910337,0.0001284642,0.000123123,0.00006991863,0.001014041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1146072,"threshold_uncertainty_score":0.9999856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093173150811834,"score_gpt":0.22824594254523,"score_spread":0.2173142110371117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}