{"id":"W4401517042","doi":"10.1002/mds.29960","title":"Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa‐Induced Dyskinesia","year":2024,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health; Idorsia Pharmaceuticals; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Wellcome Trust; McGill University; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dyskinesia; Levodopa; Odds ratio; LRRK2; Parkinson's disease; Internal medicine; Quartile; Hazard ratio; Medicine; Dopaminergic; Genome-wide association study; Confidence interval; Oncology; Single-nucleotide polymorphism; Disease; Genotype; Dopamine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005556536,0.0004504678,0.0003830678,0.0006133874,0.0003166554,0.0006500848,0.000316557,0.0005555829,0.003434056],"category_scores_gemma":[0.001853296,0.0002384562,0.001117842,0.001044926,0.0002621216,0.000189989,0.0004419142,0.0005967176,0.0002313663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957641,"about_ca_system_score_gemma":0.000242795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004997198,"about_ca_topic_score_gemma":0.003808659,"domain_scores_codex":[0.9994954,0.0001577151,0.00006057991,0.0001697381,0.00005626071,0.00006037724],"domain_scores_gemma":[0.9982353,0.0006570576,0.0006764276,0.0001362082,0.0000979032,0.0001970284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007168858,0.00002838728,0.9931826,0.00002530069,0.0007225352,0.000413456,0.00004340589,0.0002763298,0.001979041,0.00008322665,0.0001704459,0.00235823],"study_design_scores_gemma":[0.00002548064,0.00008646303,0.9974346,0.000011318,0.0002987115,0.0005461121,0.0000401224,0.0009861896,0.000219811,0.0001372879,0.0002078459,0.00000624993],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976781,0.0007535437,0.0005252429,0.0001069624,0.00001504657,0.000004883077,0.0004511063,0.00002169958,0.0004434179],"genre_scores_gemma":[0.9992773,0.00008634162,0.0001696132,0.00001911553,0.000009825785,0.000003466087,0.0002236327,0.000004981992,0.0002058512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004997198,"threshold_uncertainty_score":0.01148808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093173150811834,"score_gpt":0.22824594254523,"score_spread":0.2173142110371117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}