{"id":"W4401521631","doi":"10.1186/s40478-024-01833-9","title":"Genomic profiles and clinical presentation of chordoma","year":2024,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institutes of Health; National Cancer Institute; Chordoma Foundation","keywords":"Chordoma; Medicine; Oncology; Prostate cancer; Breast cancer; Internal medicine; Cancer; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001927112,0.00008226329,0.0001932664,0.00006420707,0.00007605967,0.00002149061,0.0001612521,0.00004366845,0.00002829655],"category_scores_gemma":[0.0001844855,0.00006166432,0.00007860058,0.0001330604,0.0002721828,0.00005905722,0.0002278783,0.0001954249,0.00002185092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001038852,"about_ca_system_score_gemma":0.00003363508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001045232,"about_ca_topic_score_gemma":0.000002426103,"domain_scores_codex":[0.9991323,0.0002047248,0.0003118457,0.0001940438,0.00007191642,0.00008513986],"domain_scores_gemma":[0.9985068,0.0005207531,0.00006366098,0.0008081736,0.00004323325,0.00005741889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000589059,0.001550568,0.9073881,0.0001219643,0.0001360113,0.0001706101,0.0003041843,2.271847e-7,0.03572417,0.006359243,0.001334832,0.04685118],"study_design_scores_gemma":[0.0003128189,0.0003791001,0.9918689,0.00006668418,0.0001910181,0.0001755572,0.00003542803,0.000351487,0.0003183022,0.0002207874,0.006029836,0.0000500705],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869578,0.00342907,0.000007746889,0.005270315,0.00006089533,0.0003685667,0.00002160332,0.00008956862,0.003794411],"genre_scores_gemma":[0.9882284,0.008721706,0.002575077,0.0001228468,0.00002294696,0.0000534265,0.00005080331,0.00001376049,0.0002110028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0844808,"threshold_uncertainty_score":0.2514598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08372458652952104,"score_gpt":0.3860653401939865,"score_spread":0.3023407536644654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}