{"id":"W4401526123","doi":"10.1016/j.bbi.2024.08.016","title":"Proteomic evidence of depression-associated astrocytic dysfunction in the human male olfactory bulb","year":2024,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of Manitoba; CancerCare Manitoba; Research Manitoba; Jewish General Hospital; McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Olfactory bulb; Depression (economics); In situ hybridization; Biology; Gene; Proteome; Endocrinology; Internal medicine; Gene expression; Psychology; Physiology; Medicine; Bioinformatics; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005143906,0.0001076562,0.0001057944,0.0001224977,0.0002276554,0.00009550752,0.0001944255,0.00005252955,0.0001262051],"category_scores_gemma":[0.000493078,0.00008140842,0.00004247834,0.0002704998,0.00007516518,0.0002985323,0.00005588217,0.000329989,0.00001047678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000272801,"about_ca_system_score_gemma":0.00003672493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004391457,"about_ca_topic_score_gemma":0.00001430651,"domain_scores_codex":[0.9985102,0.0006390574,0.0002548367,0.0002312911,0.0002321301,0.0001324659],"domain_scores_gemma":[0.9992865,0.0003473263,0.00007049381,0.0002471125,0.00002007262,0.00002844352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001074881,0.00007202509,0.002432173,0.00002567633,4.959774e-7,0.0000160708,0.0003974432,0.00000407775,0.9956899,0.0003687108,0.0001114948,0.0008711344],"study_design_scores_gemma":[0.0002486132,0.0001423808,0.1806803,0.0001337889,0.00001431603,0.00004898807,0.00006542449,0.0002492609,0.8181924,0.00008448983,0.00005098125,0.00008897582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988528,0.00005107462,0.00006903037,0.0001958233,0.0001693673,0.0004913522,0.000007575895,0.00005862321,0.0001043293],"genre_scores_gemma":[0.9991826,0.00002507278,0.00000985627,0.000213612,0.00001467686,0.00008417006,0.000003735942,0.00001110028,0.0004551916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1782482,"threshold_uncertainty_score":0.3319739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08337763528291396,"score_gpt":0.3138942211915607,"score_spread":0.2305165859086468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}