{"id":"W4401527030","doi":"10.1200/jco.2024.42.23_suppl.215","title":"Precision medicine-based platform to guide the treatment of EML4-ALK driven lung cancers and other NSCLC in real time.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Richard Tam Foundation","keywords":"Medicine; Lung cancer; Oncology; Precision medicine; Crizotinib; Internal medicine; Cancer research; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107492,0.0008792107,0.0008056141,0.0008502497,0.000300852,0.001484905,0.0009552666,0.001802775,0.0040866],"category_scores_gemma":[0.001169882,0.0004598434,0.0008477616,0.0003137989,0.0004648866,0.000807489,0.001034175,0.001372658,0.002525103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000769927,"about_ca_system_score_gemma":0.0007220278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005457696,"about_ca_topic_score_gemma":0.000966396,"domain_scores_codex":[0.9992724,0.00009633195,0.00004189546,0.0001825519,0.0003402202,0.00006656098],"domain_scores_gemma":[0.9995587,0.0001098691,0.00008582009,0.0000544621,0.0001391801,0.00005191609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0003718512,0.0001792391,0.002160382,0.0009615059,0.0001795017,0.0004997498,0.00008649584,0.007901283,0.8174485,0.003807801,0.01606859,0.1503351],"study_design_scores_gemma":[0.0001068358,0.001212718,0.002349656,0.0001754279,0.0002379434,0.001317482,0.0000816716,0.03707577,0.8000171,0.004172551,0.1531276,0.0001253704],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1370202,0.05645882,0.7289571,0.007759233,0.002837606,0.001794446,0.0131532,0.01807519,0.03394425],"genre_scores_gemma":[0.5213947,0.01736199,0.4234545,0.007294412,0.000591742,0.001724907,0.008958011,0.0008490739,0.01837058],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0040866,"threshold_uncertainty_score":0.0136711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0898393799532811,"score_gpt":0.5290685278054648,"score_spread":0.4392291478521836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}