{"id":"W4401529334","doi":"10.1186/s40164-024-00550-2","title":"M2-like tumor-associated macrophage-secreted CCL2 facilitates gallbladder cancer stemness and metastasis","year":2024,"lang":"en","type":"article","venue":"Experimental Hematology and Oncology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"","keywords":"Cancer research; Cancer stem cell; Metastasis; Tumor-associated macrophage; CD44; CCR2; Biology; Tumor microenvironment; Chemokine; Epithelial–mesenchymal transition; CCL5; CCL2; Cancer; Chemokine receptor; Stem cell; Immune system; Immunology; Cell; T cell; Cell biology; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003284294,0.0004164487,0.0008482583,0.0001872173,0.000347318,0.0000347769,0.0001980431,0.0006331611,0.00375434],"category_scores_gemma":[0.00003724085,0.0003709056,0.0001068881,0.0001939262,0.001330876,0.0001583104,0.0003073098,0.0006112211,0.0002748522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666312,"about_ca_system_score_gemma":0.0001831959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003256049,"about_ca_topic_score_gemma":0.0001227108,"domain_scores_codex":[0.9974263,0.0005353282,0.0005083717,0.0007834301,0.00005069435,0.0006959264],"domain_scores_gemma":[0.9989719,0.0005545355,0.0001193636,0.0002341034,0.00005303064,0.00006705368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001401294,0.0009854926,0.008788295,0.0005916577,0.004151025,0.001560888,0.0148,0.000004051224,0.8907937,0.01699726,0.04095214,0.01897424],"study_design_scores_gemma":[0.004040014,0.001200608,0.00152088,0.0001949102,0.000302748,0.003839005,0.00650711,0.00006766338,0.7555123,0.0004467831,0.225534,0.0008339925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6542219,0.3404881,0.00001697425,0.0004300234,0.003156229,0.0003145787,0.000102759,0.0001845484,0.001084939],"genre_scores_gemma":[0.9937999,0.001137284,0.0000972887,0.000742838,0.00003051092,0.0003270749,0.0001014204,0.00004655541,0.003717137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.339578,"threshold_uncertainty_score":0.9998743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659646511234917,"score_gpt":0.309311820193213,"score_spread":0.2927153550808638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}