{"id":"W4401534435","doi":"10.3390/biomedicines12081843","title":"Upholding or Breaking the Law of Superposition in Pharmacokinetics","year":2024,"lang":"en","type":"review","venue":"Biomedicines","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Mitacs","keywords":"Superposition principle; ADME; Pharmacokinetics; Dosing; Pharmacology; Law; Drug; Drug development; Saturation (graph theory); Medicine; Computer science; Mathematics; Political science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002004103,0.0006909121,0.001576403,0.001284772,0.0003741106,0.00176861,0.001268923,0.00158885,0.003156154],"category_scores_gemma":[0.002495511,0.0004611656,0.0008520258,0.001418249,0.002864737,0.003673155,0.001506222,0.004416177,0.002096241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008652469,"about_ca_system_score_gemma":0.001321141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009931973,"about_ca_topic_score_gemma":0.001264209,"domain_scores_codex":[0.9989837,0.0003156179,0.00009441189,0.0001658648,0.0003828721,0.00005754548],"domain_scores_gemma":[0.9987883,0.0008804356,0.0001030967,0.00007906008,0.0001143862,0.00003472484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008542393,0.00007443151,0.0002441754,0.01765303,0.0001765899,0.000427592,0.0003723777,0.002133896,0.006047116,0.1964639,0.02299813,0.7533233],"study_design_scores_gemma":[0.00001890366,0.0001360927,0.0004192509,0.00229419,0.00008524444,0.001069419,0.00008510789,0.0007237759,0.002487723,0.06442139,0.9282073,0.00005158388],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009085576,0.9779992,0.008894454,0.002536343,0.001154968,0.00002161981,0.00004566249,0.00006422872,0.008375064],"genre_scores_gemma":[0.01233496,0.9745471,0.00539661,0.00243872,0.001069792,0.00004159831,0.00006750179,0.0000314862,0.004072275],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003156154,"threshold_uncertainty_score":0.01059884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3366301928159,"score_gpt":0.5600501622615701,"score_spread":0.2234199694456702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}