{"id":"W4401535018","doi":"10.1513/annalsats.202402-215oc","title":"Blood Transcriptomic and Inflammatory Protein Biomarkers Associated with Imminent Pulmonary Exacerbation Risk in Cystic Fibrosis","year":2024,"lang":"en","type":"article","venue":"Annals of the American Thoracic Society","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; St. Paul's Hospital; University of British Columbia","funders":"Mitacs; Cystic Fibrosis Foundation Therapeutics","keywords":"Medicine; Cystic fibrosis; Exacerbation; Transcriptome; Biomarker; Internal medicine; Bioinformatics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004830166,0.0002497744,0.0003340174,0.0006619173,0.0002334998,0.0006835203,0.0001120605,0.0004716298,0.001036903],"category_scores_gemma":[0.001878518,0.0001229689,0.0001604214,0.000530459,0.0002162888,0.0002321853,0.0002025821,0.0005181286,0.0001692553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969811,"about_ca_system_score_gemma":0.0002005182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001168662,"about_ca_topic_score_gemma":0.00166907,"domain_scores_codex":[0.9997697,0.00007341418,0.0000192901,0.00005194874,0.00004459008,0.000041044],"domain_scores_gemma":[0.9991789,0.0003461635,0.0002525396,0.0000405311,0.0001078692,0.00007387612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002360616,0.0001344616,0.9084502,0.00007807444,0.0001448861,0.0004610191,0.0001822075,0.000537298,0.0679388,0.0001537024,0.0005979394,0.01896073],"study_design_scores_gemma":[0.00001751593,0.0002874791,0.9927883,0.00002665186,0.0000710406,0.0004246896,0.0001686288,0.001500035,0.003916517,0.0002810565,0.0005053316,0.00001279684],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971153,0.0008836912,0.0007540025,0.0001901528,0.00001885526,0.000009730685,0.0005490861,0.00001178833,0.000467352],"genre_scores_gemma":[0.9979772,0.0002565595,0.0008522838,0.0001069528,0.00002419032,0.00001757477,0.0004328467,0.000004211593,0.0003281919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168662,"threshold_uncertainty_score":0.003468812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548295781082712,"score_gpt":0.3323805084348282,"score_spread":0.3068975506240011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}