{"id":"W4401545208","doi":"10.1101/2024.08.12.607623","title":"Human MeCP2 binds to promoters and inhibits transcription in an unmethylated S. cerevisiae genome","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"","keywords":"MECP2; DNA methylation; Biology; Genetics; Histone methylation; Nucleosome; Histone; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008186372,0.0003879653,0.0002054617,0.0001751016,0.0001159807,0.000241558,0.0002029784,0.0001647172,0.001835188],"category_scores_gemma":[0.000104873,0.0001754897,0.0001944609,0.0001495531,0.0001362027,0.00006443674,0.0002262483,0.0002822746,0.000701279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003270984,"about_ca_system_score_gemma":0.0002047379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003952816,"about_ca_topic_score_gemma":0.005298584,"domain_scores_codex":[0.9998971,0.00001069863,0.000006289499,0.00002419245,0.00004393209,0.00001768758],"domain_scores_gemma":[0.9999633,0.000008965077,0.000004837071,0.000007122066,0.000004349689,0.00001142427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006272107,0.00001146166,0.0002504029,0.00003060103,0.000009315901,0.00006960701,0.000009205926,0.0002044592,0.9976358,0.0001198156,0.0002164493,0.001380236],"study_design_scores_gemma":[0.000009815125,0.00003553513,0.002182881,0.000003764081,0.000004826709,0.00009372337,0.00001044837,0.001914469,0.9921317,0.00005031393,0.003560084,0.000002464696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822765,0.002708931,0.007099576,0.0002039445,0.00009550995,0.00002105702,0.001991958,0.0005583266,0.005044176],"genre_scores_gemma":[0.9783004,0.001127895,0.005012495,0.0001178947,0.00001279035,0.00002353586,0.003166449,0.0001474429,0.01209103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003952816,"threshold_uncertainty_score":0.007859588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170563178733007,"score_gpt":0.231688983776276,"score_spread":0.219983351988946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}