{"id":"W4401571543","doi":"10.7554/elife.93968.2","title":"Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Allosteric regulation; In silico; CXCR4; Cell biology; Chemokine receptor; Receptor; Internalization; Biophysics; Biology; Docking (animal); Small molecule; Ligand (biochemistry); Chemistry; Chemokine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081479,0.0002192118,0.0002174441,0.00008240949,0.00009504922,0.0001828897,0.0002797382,0.0001796778,0.001404333],"category_scores_gemma":[0.0001073851,0.00008650493,0.0001690412,0.0000780697,0.000171252,0.0001098667,0.0001484401,0.0002789747,0.0002650804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003759647,"about_ca_system_score_gemma":0.000187393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009336638,"about_ca_topic_score_gemma":0.0009582881,"domain_scores_codex":[0.9999472,0.000007101266,0.000002830162,0.00001158642,0.00001664574,0.00001456413],"domain_scores_gemma":[0.9999735,0.000006860198,0.000007890966,0.000002496675,0.000003637692,0.000005541842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001758993,0.00006569639,0.0002530497,0.00006659554,0.000009095775,0.00004328593,0.000009936015,0.003644504,0.9921668,0.0004542972,0.0001749569,0.002935942],"study_design_scores_gemma":[0.00007329914,0.0004075636,0.0005202381,0.000004435262,0.00001841669,0.00008388701,0.00001181908,0.02210754,0.9745359,0.00007867104,0.002149938,0.000008252981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989637,0.0006480366,0.007446379,0.0001456417,0.00002514551,0.00004468967,0.000258316,0.000157718,0.001637217],"genre_scores_gemma":[0.9921962,0.0002804874,0.006473048,0.0000478183,0.000002805256,0.00002786994,0.0001560854,0.00001799206,0.0007976603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404333,"threshold_uncertainty_score":0.004697978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011141605316654,"score_gpt":0.2505068738561311,"score_spread":0.2393652685394771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}