{"id":"W4401573514","doi":"10.7554/elife.93260.4","title":"Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; University of Manitoba; Children's Hospital Research Institute of Manitoba; Impact; SickKids Foundation; BC Children's Hospital; University of Toronto; University of Alberta; Thrombosis and Atherosclerosis Research Institute; Population Health Research Institute; McMaster University; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Offspring; dNaM; Pregnancy; Medicine; Epigenetics; DNA methylation; Cord blood; Cohort; Cohort study; Physiology; Obstetrics; Demography; Internal medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006483482,0.0002427697,0.0002005604,0.0003576178,0.0002111299,0.0003467365,0.000234753,0.0002827438,0.00219501],"category_scores_gemma":[0.001830577,0.0001312702,0.0003961493,0.0004197021,0.0002636769,0.0001164197,0.0004628625,0.0003390142,0.0001343425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462665,"about_ca_system_score_gemma":0.0001921852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006041726,"about_ca_topic_score_gemma":0.00578276,"domain_scores_codex":[0.9997707,0.00005720665,0.0000192199,0.00009369323,0.00003058952,0.00002855935],"domain_scores_gemma":[0.9991703,0.000237394,0.0002895225,0.0001130434,0.00007842261,0.0001114024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002321133,0.00000936227,0.9953887,0.000009835221,0.0001868621,0.00006128599,0.000105132,0.00005142855,0.002305408,0.00004089806,0.00004505365,0.00156378],"study_design_scores_gemma":[0.000004888761,0.00004002609,0.9990214,0.000004068117,0.0001037,0.0001155816,0.00006901642,0.0002343961,0.0002877918,0.00003965416,0.00007760724,0.000001832394],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994208,0.00008163033,0.0001246687,0.00002023344,0.000002293017,0.000001792022,0.0001555909,0.000002801146,0.0001902532],"genre_scores_gemma":[0.9995821,0.00003523463,0.0001233607,0.00001004152,0.00000181296,0.000003189946,0.0001240168,0.000002089003,0.000118238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006041726,"threshold_uncertainty_score":0.01201314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191714772933242,"score_gpt":0.2795752996305376,"score_spread":0.2576581519012052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}