{"id":"W4401576279","doi":"10.1073/pnas.2321686121","title":"Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Faculty of Medicine and Health, University of Sydney; Monash Biomedicine Discovery Institute, Monash University; National Health and Medical Research Council; Australian Research Council; National Institutes of Health; Vlaams Instituut voor Biotechnologie; CSL Limited; Monash University; Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Stichting Tegen Kanker; Universiteit Gent; Department of Health and Aged Care, Australian Government; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Cardiff University; Wellcome Trust; Brigham and Women's Hospital","keywords":"CD1D; Sphingomyelin; Natural killer T cell; T-cell receptor; Ceramide; Endoplasmic reticulum; Cell biology; Biology; Antigen; Epitope; CD1; Chemistry; T cell; Biochemistry; Immunology; Apoptosis; Immune system; CD8; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252653,0.0002482138,0.0001703347,0.000359589,0.0001189649,0.0003171267,0.0001527998,0.0003450993,0.0009314664],"category_scores_gemma":[0.000164164,0.0001180516,0.0001612048,0.0001958614,0.0001182204,0.0003062013,0.0003003949,0.0002926513,0.000407243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660923,"about_ca_system_score_gemma":0.000094028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002133743,"about_ca_topic_score_gemma":0.00034119,"domain_scores_codex":[0.9999092,0.00001111291,0.000005017538,0.00002685573,0.00002579348,0.00002205484],"domain_scores_gemma":[0.9999472,0.000009261019,0.00001262518,0.00000389858,0.00001394192,0.00001307788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005081837,0.000003244066,0.000616861,0.0000133981,0.000002693095,0.00001960869,0.000008719098,0.0000220784,0.9982831,0.00002304549,0.00001434025,0.0009420906],"study_design_scores_gemma":[0.00001100824,0.0001150446,0.01272529,0.000006538349,0.0000217135,0.0002586234,0.00008024674,0.002227204,0.9832432,0.0001767124,0.001126488,0.000007980976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881671,0.000793519,0.00932967,0.00008186459,0.00001668983,0.00003654896,0.0005552828,0.00009114522,0.0009281894],"genre_scores_gemma":[0.9853171,0.0007340631,0.01178902,0.0001722737,0.00001223242,0.00005436156,0.0007123474,0.00003832002,0.001170385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009314664,"threshold_uncertainty_score":0.003116071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02535459711953787,"score_gpt":0.2960418518276657,"score_spread":0.2706872547081278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}