{"id":"W4401578078","doi":"10.7554/elife.99373","title":"Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of General Medical Sciences; Japan Society for the Promotion of Science; LEO Fondet; Biotechnology and Biological Sciences Research Council; Wellcome Trust; National Cancer Institute; Daiichi Sankyo Foundation of Life Science; Japan Science and Technology Agency; Uehara Memorial Foundation","keywords":"Endosome; Chemokine receptor; Cell biology; Chemokine; CCL25; CC chemokine receptors; Receptor; Cell migration; Cell; Biology; Genetics; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618624,0.0003127151,0.0002893845,0.0002867972,0.0003462884,0.0007275546,0.0001907388,0.0005352859,0.001178342],"category_scores_gemma":[0.00010676,0.0001703054,0.0002843739,0.0001273501,0.0003589846,0.0006663781,0.0004851503,0.0005942197,0.0009654823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007460461,"about_ca_system_score_gemma":0.0003290673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006047604,"about_ca_topic_score_gemma":0.0008721228,"domain_scores_codex":[0.9998041,0.0000245617,0.000008609412,0.0000401826,0.00004537857,0.0000772383],"domain_scores_gemma":[0.9999102,0.000005125276,0.00002539579,0.000007032579,0.00002578883,0.00002651786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001165217,0.000007249452,0.0002953587,0.00005504355,0.000004598681,0.0001090959,0.00002917303,0.00006821121,0.9955454,0.0018842,0.0001612484,0.001723826],"study_design_scores_gemma":[0.00004777795,0.000146101,0.02544041,0.00004799656,0.00002425331,0.0005925528,0.0002853179,0.002754106,0.9492226,0.001376803,0.02003503,0.00002703174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597206,0.01319113,0.01635013,0.0007641659,0.0001073191,0.00009340714,0.0007829585,0.0002435475,0.008746633],"genre_scores_gemma":[0.9854289,0.004933272,0.004251291,0.0001660956,0.00002703997,0.00004735548,0.0004819138,0.00005565034,0.0046086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178342,"threshold_uncertainty_score":0.005412936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245089612734895,"score_gpt":0.238686503347403,"score_spread":0.2262356072200541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}