{"id":"W4401580119","doi":"10.7554/elife.99373.1","title":"Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"","keywords":"Cell biology; Chemokine receptor; Endosome; G protein-coupled receptor; CCR1; Chemotaxis; CCL21; C-C chemokine receptor type 7; Biology; Signal transduction; C-C chemokine receptor type 6; Receptor; Chemokine; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525141,0.0002968642,0.0002460901,0.0002858674,0.0002768779,0.0005533899,0.0001619829,0.0004798497,0.001642235],"category_scores_gemma":[0.0001333054,0.0001510512,0.0002422582,0.0001317221,0.0002983709,0.0004497457,0.000469177,0.0005712699,0.001325556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000546596,"about_ca_system_score_gemma":0.0002344468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004832869,"about_ca_topic_score_gemma":0.0005338977,"domain_scores_codex":[0.9998524,0.00001676578,0.000005411911,0.00002935736,0.00003839749,0.00005769343],"domain_scores_gemma":[0.9999174,0.000008158678,0.00001982584,0.000009149632,0.00002141122,0.00002401252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001512982,0.000008519891,0.0003257135,0.00004342922,0.000004436493,0.0001321256,0.00002122428,0.00009056822,0.9953429,0.002051459,0.0002321679,0.001596197],"study_design_scores_gemma":[0.00004128279,0.00008533559,0.01595358,0.00001894144,0.00001171661,0.0004577944,0.0001263966,0.003338894,0.9682508,0.001328565,0.01037421,0.00001246917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687405,0.005338639,0.01407818,0.0006200434,0.0001120551,0.00004980241,0.0009149629,0.0002415189,0.009904275],"genre_scores_gemma":[0.9855032,0.001693419,0.004594879,0.0001093695,0.00002768941,0.00003269784,0.0008343576,0.00007532342,0.007128935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642235,"threshold_uncertainty_score":0.00549382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661512447026067,"score_gpt":0.2485366383298133,"score_spread":0.2319215138595526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}