{"id":"W4401583246","doi":"10.1002/alz.14095","title":"Omics‐derived biological modules reflect metabolic brain changes in Alzheimer's disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Diet and metabolism studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Aging; Instituto Serrapilheira; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Weston Brain Institute; Canadian Institutes of Health Research; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Fondation Brain Canada; Alzheimer's Association","keywords":"Disease; Alzheimer's disease; Neuroscience; Computational biology; Biology; Bioinformatics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005528516,0.0006735541,0.0005740671,0.001832974,0.0003066884,0.000892034,0.0002129399,0.0002469094,0.00182428],"category_scores_gemma":[0.0008624862,0.0001579999,0.001093367,0.001783647,0.000259497,0.0003644005,0.0006076165,0.0002954142,0.0002067753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004037005,"about_ca_system_score_gemma":0.0004720895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00178678,"about_ca_topic_score_gemma":0.001800807,"domain_scores_codex":[0.9996554,0.00006444528,0.00002646333,0.0001355356,0.00005890484,0.00005933887],"domain_scores_gemma":[0.9996376,0.0001119327,0.0001273202,0.00003542669,0.00005173419,0.00003605562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001053438,0.0001506044,0.5992483,0.0007074022,0.001823224,0.0003819518,0.0003711094,0.007002681,0.3329589,0.001318774,0.001499174,0.05348445],"study_design_scores_gemma":[0.00001348364,0.0001438956,0.9722602,0.0000413531,0.0005298848,0.0003329186,0.0002296732,0.01408515,0.008778659,0.002236428,0.001324678,0.00002360556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778932,0.001177572,0.01265206,0.000171226,0.00001647798,0.00003968866,0.007068319,0.0001853359,0.0007961739],"genre_scores_gemma":[0.9880321,0.0003239351,0.007202987,0.00006211267,0.00001347006,0.00005390434,0.003885397,0.00002172578,0.0004043396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001832974,"threshold_uncertainty_score":0.00610286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05879777755106335,"score_gpt":0.3217995010794955,"score_spread":0.2630017235284321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}