{"id":"W4401583589","doi":"10.3390/cancers16162839","title":"Potentiating Salvage Radiotherapy in Radiorecurrent Prostate Cancer Through Anti-CTLA4 Therapy: Implications from a Syngeneic Model","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Movember Canada; Prostate Cancer Canada; Sunnybrook Foundation; Canadian Institutes of Health Research; Sunnybrook Research Institute; Movember Foundation","keywords":"Prostate cancer; CD8; Medicine; Immune system; Cancer research; Radiation therapy; Immune checkpoint; T cell; Cancer; Isotype; Immunotherapy; Oncology; Internal medicine; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006993748,0.0009039286,0.0006996501,0.0008205336,0.0002464323,0.0004962201,0.001092191,0.0007025365,0.001419289],"category_scores_gemma":[0.0001729635,0.0002831732,0.0007220946,0.0002895258,0.0005513022,0.0004563396,0.0002796774,0.002164449,0.0004136579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004248208,"about_ca_system_score_gemma":0.0003644757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006091592,"about_ca_topic_score_gemma":0.0008338987,"domain_scores_codex":[0.9996123,0.0001051714,0.00003138656,0.00006866637,0.0001027835,0.00007973221],"domain_scores_gemma":[0.9997801,0.00003964165,0.00005844732,0.0000423193,0.00001618181,0.00006328745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009807651,0.001760309,0.000236905,0.0001438514,0.00002762192,0.0001718433,0.00005945297,0.0005037347,0.9927563,0.0005109776,0.0001966664,0.002651654],"study_design_scores_gemma":[0.0004851494,0.01981809,0.002180344,0.0000378928,0.0001464482,0.0008605103,0.00006439994,0.002912838,0.9690544,0.0001989299,0.004221237,0.00001968096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874709,0.003132771,0.005641443,0.000414992,0.0001967081,0.0003805794,0.0006299948,0.0001737871,0.001958831],"genre_scores_gemma":[0.9850839,0.002932211,0.00634349,0.0001975798,0.0001056437,0.0004907608,0.0008981028,0.0000477824,0.003900515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001419289,"threshold_uncertainty_score":0.004747927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0347621149262862,"score_gpt":0.3329525595968342,"score_spread":0.2981904446705479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}