{"id":"W4401586147","doi":"10.1002/ajh.27455","title":"Imatinib versus newer generation <scp>TKIs</scp> for upfront therapy in chronic phase <scp>chronic myeloid leukemia</scp>: What is the rationale for paying more to get the same survival benefit?","year":2024,"lang":"en","type":"letter","venue":"American Journal of Hematology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Myeloid leukemia; Imatinib; Hematology; Internal medicine; Transplantation; Imatinib mesylate; Disease; Oncology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005002766,0.0009110717,0.002326091,0.0008707441,0.001063349,0.002903477,0.002812485,0.006346444,0.005519739],"category_scores_gemma":[0.01997261,0.0003955273,0.001381283,0.000821078,0.001140884,0.002813488,0.0004237213,0.01396733,0.002637835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001666708,"about_ca_system_score_gemma":0.002218702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157555,"about_ca_topic_score_gemma":0.002948158,"domain_scores_codex":[0.9979903,0.0007649633,0.0002781519,0.0001996558,0.0006012977,0.0001657373],"domain_scores_gemma":[0.986453,0.007449706,0.001136524,0.0001868798,0.003483076,0.001290803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008212336,0.00008871737,0.0006053176,0.0006841352,0.00009400192,0.0003673309,0.00004623961,0.0001110175,0.0001940027,0.0007121877,0.9678944,0.02838135],"study_design_scores_gemma":[0.00129267,0.0006926338,0.003752883,0.001994395,0.0006843976,0.001433253,0.0002918047,0.001457266,0.0009866662,0.003981057,0.9833213,0.0001118271],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00204426,0.03339181,0.0003136144,0.6557222,0.304211,0.00006997334,0.0002651934,0.00008627371,0.003895665],"genre_scores_gemma":[0.01176958,0.02326999,0.0005192602,0.4201014,0.5370246,0.0000802107,0.0001390202,0.00007236743,0.007023598],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006346444,"threshold_uncertainty_score":0.02645749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0374721474033498,"score_gpt":0.3296271561682365,"score_spread":0.2921550087648866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}