{"id":"W4401587890","doi":"10.1002/smsc.202400145","title":"Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery","year":2024,"lang":"en","type":"article","venue":"Small Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; RMIT University; Australian Synchrotron; Australian Institute of Nuclear Science and Engineering; Australian Government; Australian Nuclear Science and Technology Organisation; Ontario Ministry of Natural Resources and Forestry","keywords":"Nanocarriers; Antimicrobial; Chemistry; Cationic polymerization; Drug delivery; Combinatorial chemistry; Biophysics; Lipid bilayer; Small-angle X-ray scattering; Membrane; Biochemistry; Organic chemistry; Scattering; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002757137,0.0001001112,0.00007486214,0.00005136061,0.0002043441,0.0001267002,0.0002652627,0.00006165093,0.00001414923],"category_scores_gemma":[0.00004972714,0.00008455717,0.00007712047,0.0001831719,0.0002213336,0.000009068563,0.0000951468,0.00004953158,0.000007705556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002266048,"about_ca_system_score_gemma":0.0003730085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001662954,"about_ca_topic_score_gemma":0.00002100331,"domain_scores_codex":[0.9990392,0.000008211081,0.0001059985,0.0004313487,0.00009611418,0.00031915],"domain_scores_gemma":[0.9996198,0.000006869335,0.00001908843,0.000182693,0.0000801084,0.00009147517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001688412,0.000005476168,0.0001192538,0.00002030209,0.000006040308,0.000002839158,0.00005654976,0.00002009122,0.993347,0.0001366443,0.001262342,0.005006577],"study_design_scores_gemma":[0.0001477188,0.0001539544,0.00008106897,0.00001909163,0.00001770733,0.00002154342,0.00004024018,0.0002071308,0.9212142,0.000005744604,0.07796015,0.0001314572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955257,0.0001522775,0.001271716,0.0001258035,0.002013096,0.0001904681,0.00002391633,0.00002604927,0.0006710039],"genre_scores_gemma":[0.996427,0.00003574149,0.001556427,0.0003597021,0.0007278961,0.0000152759,0.00002908553,0.0000120304,0.0008368642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07669781,"threshold_uncertainty_score":0.3448142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483686576371372,"score_gpt":0.2582466617345212,"score_spread":0.2434097959708075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}