{"id":"W4401587890","doi":"10.1002/smsc.202400145","title":"Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery","year":2024,"lang":"en","type":"article","venue":"Small Science","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; RMIT University; Australian Synchrotron; Australian Institute of Nuclear Science and Engineering; Australian Government; Australian Nuclear Science and Technology Organisation; Ontario Ministry of Natural Resources and Forestry","keywords":"Nanocarriers; Antimicrobial; Chemistry; Cationic polymerization; Drug delivery; Combinatorial chemistry; Biophysics; Lipid bilayer; Small-angle X-ray scattering; Membrane; Biochemistry; Organic chemistry; Scattering; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711706,0.0003126605,0.0001704095,0.0001783721,0.0001216951,0.0002935194,0.0001929129,0.0003363201,0.0006157429],"category_scores_gemma":[0.0001271675,0.00009942588,0.0002105517,0.00009460017,0.0001852326,0.0003525913,0.0002985118,0.0003353124,0.0003902077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000405968,"about_ca_system_score_gemma":0.0001780211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003040278,"about_ca_topic_score_gemma":0.0003888326,"domain_scores_codex":[0.9999034,0.00001615806,0.000006705543,0.00002524171,0.00003399093,0.00001449253],"domain_scores_gemma":[0.9999601,0.000009120802,0.00001357435,0.000003234424,0.000007931798,0.000006018493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000195739,0.00001299299,0.00003647788,0.00005906079,0.000005560847,0.00003054814,0.00001439786,0.0002251328,0.9927603,0.0005255501,0.00008383606,0.006226693],"study_design_scores_gemma":[0.00001012804,0.000154243,0.0001635215,0.00000960547,0.00001243628,0.0001115459,0.00001208014,0.001803681,0.9891899,0.0001698831,0.008355455,0.000007574661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7937095,0.035324,0.1530772,0.001035162,0.0003378211,0.0003427801,0.000309186,0.000940688,0.01492371],"genre_scores_gemma":[0.9203129,0.01051246,0.06085999,0.000432343,0.00004653144,0.0001520651,0.0001504135,0.00006927249,0.007463949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006157429,"threshold_uncertainty_score":0.002945483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483686576371372,"score_gpt":0.2582466617345212,"score_spread":0.2434097959708075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}