{"id":"W4401588211","doi":"10.20944/preprints202408.0366.v1","title":"3D-Q-FISH/TRF2 Nanotechnology Identifies a Progressively Disturbed Telomere/ Shelterin/Lamin AC Complex as the Common Pathogenic, Molecular/Spatial Denominator of Classical Hodgkin Lymphoma","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Ontario Genomics; McGill University; Jewish General Hospital","funders":"","keywords":"Telomere; Shelterin; Germinal center; Biology; Lymphoma; Cancer research; Mantle cell lymphoma; B cell; Immunology; Genetics; DNA; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238854,0.0001585737,0.0001044742,0.0002320326,0.0001388047,0.0002635005,0.0001265579,0.0003433781,0.001082343],"category_scores_gemma":[0.00008035376,0.0001309649,0.0001311632,0.0001042362,0.0002147376,0.0002275032,0.0001991227,0.0002681776,0.0002456012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002832137,"about_ca_system_score_gemma":0.0001245013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008367519,"about_ca_topic_score_gemma":0.001313108,"domain_scores_codex":[0.9999388,0.000005712416,0.000003751492,0.00001568134,0.00002217356,0.00001394246],"domain_scores_gemma":[0.999963,0.000007773542,0.000008594587,0.000006128477,0.000007627697,0.000006853405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002143994,0.000005070576,0.0004898463,0.00003552666,0.000003664085,0.0001144843,0.00003080713,0.0001711005,0.9973035,0.0002035966,0.00007593794,0.001545037],"study_design_scores_gemma":[0.000008647467,0.0001145116,0.009978388,0.00001153476,0.00002292095,0.001257878,0.0001364707,0.003752062,0.9775424,0.0002428402,0.006920966,0.00001137598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861049,0.001801207,0.008858635,0.0001441909,0.00002062571,0.00001513214,0.0002059524,0.0001635282,0.002685839],"genre_scores_gemma":[0.992405,0.0008499914,0.004316196,0.00006813942,0.000004599888,0.0000215357,0.0002168039,0.00002552973,0.002092116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082343,"threshold_uncertainty_score":0.003620744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05595600720738127,"score_gpt":0.3444466549147986,"score_spread":0.2884906477074173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}