{"id":"W4401589509","doi":"10.3389/ffunb.2024.1447588","title":"Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans","year":2024,"lang":"en","type":"article","venue":"Frontiers in Fungal Biology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cryptococcus neoformans; Caspofungin; Capsule; Microbiology; Chemistry; Phosphate; Biology; Biochemistry; Antifungal; Fluconazole; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125678,0.0001408405,0.0003074827,0.000276014,0.00007750112,0.00001672616,0.0000349914,0.0001244433,0.00007961679],"category_scores_gemma":[0.00002245455,0.0001197028,0.00004953055,0.0002951698,0.0001323679,0.0001436196,0.00003578996,0.0002701879,0.00003155074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448662,"about_ca_system_score_gemma":0.0000366664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001233395,"about_ca_topic_score_gemma":0.000129823,"domain_scores_codex":[0.9990254,0.00004927298,0.0003204942,0.0002613403,0.00005116646,0.0002923245],"domain_scores_gemma":[0.9997152,0.00003652931,0.00002861016,0.0001308554,0.00003037683,0.00005844646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000144646,0.0002625097,0.9235619,0.0005903816,0.00006988204,0.0001331532,0.001978218,0.00008263356,0.01210914,0.001627035,0.05485447,0.004585981],"study_design_scores_gemma":[0.005219464,0.002029516,0.733705,0.0006150529,0.0001868721,0.0002447495,0.003488874,0.03065299,0.0200927,0.004723729,0.1981612,0.0008798495],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757347,0.01102521,0.001256854,0.0005727062,0.001833093,0.0006935215,0.0001212216,0.0000732843,0.008689377],"genre_scores_gemma":[0.9973239,0.0008887915,0.000766898,0.0001448669,0.00006532236,0.0001406423,0.0001117544,0.000008749745,0.0005491134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1898569,"threshold_uncertainty_score":0.4881339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105032734555639,"score_gpt":0.2759941062141364,"score_spread":0.2654908327585725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}