{"id":"W4401589509","doi":"10.3389/ffunb.2024.1447588","title":"Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans","year":2024,"lang":"en","type":"article","venue":"Frontiers in Fungal Biology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cryptococcus neoformans; Caspofungin; Capsule; Microbiology; Chemistry; Phosphate; Biology; Biochemistry; Antifungal; Fluconazole; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005576913,0.00019698,0.0001590571,0.0001919949,0.0001425498,0.0002353121,0.0001400173,0.0002089404,0.0007148243],"category_scores_gemma":[0.0001504492,0.00009961159,0.0001416568,0.0001388122,0.0001542021,0.0001663597,0.0002027338,0.0002475364,0.0001516452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336194,"about_ca_system_score_gemma":0.0001973727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003021451,"about_ca_topic_score_gemma":0.002124885,"domain_scores_codex":[0.9999012,0.00001230903,0.00001048678,0.00002086614,0.00002287953,0.00003227263],"domain_scores_gemma":[0.9999169,0.00001668656,0.00002436936,0.000009828474,0.000009494032,0.000022685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001393275,0.00002031872,0.0008468263,0.00001319469,0.000001382596,0.0001155642,0.00001677773,0.00003316977,0.9982581,0.00002311378,0.00001285632,0.0005193425],"study_design_scores_gemma":[0.00001659929,0.0004070354,0.08049174,0.00000824431,0.00001544417,0.001170639,0.0001862704,0.001725268,0.9147078,0.0001367373,0.001124538,0.000009682319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987937,0.0002257437,0.0002678166,0.00002983017,0.000004966065,0.00000992527,0.0002119786,0.00001256523,0.0004434489],"genre_scores_gemma":[0.9985843,0.0001337007,0.0004718743,0.00002407106,0.000002374813,0.00001113868,0.0002444352,0.000005065524,0.0005231348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003021451,"threshold_uncertainty_score":0.006007731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105032734555639,"score_gpt":0.2759941062141364,"score_spread":0.2654908327585725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}