{"id":"W4401595054","doi":"10.1080/14737140.2024.2393251","title":"Strategies for the prevention or reversal of PARP inhibitor resistance","year":2024,"lang":"en","type":"review","venue":"Expert Review of Anticancer Therapy","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; PARP inhibitor; Pharmacology; Oncology; Poly ADP ribose polymerase; Internal medicine; Cancer research; Intensive care medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009751793,0.000610794,0.003480708,0.0001450404,0.0000689569,0.00002791306,0.000438511,0.0002424264,0.0006495358],"category_scores_gemma":[0.00009053211,0.0003044002,0.001880071,0.0007812747,0.0003918941,0.0001205756,0.00003695422,0.0003780182,0.00001312646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000921,"about_ca_system_score_gemma":0.002452035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001219011,"about_ca_topic_score_gemma":0.000008686222,"domain_scores_codex":[0.9963186,0.000231198,0.001872638,0.0005968417,0.000654441,0.0003262224],"domain_scores_gemma":[0.9966799,0.000602479,0.001152008,0.001110807,0.0003778249,0.00007698806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004722654,0.0001249386,9.563707e-8,0.2774587,0.001113521,0.000004543167,0.000163348,2.845987e-8,0.00005270634,0.001344268,0.1245686,0.594697],"study_design_scores_gemma":[0.0005912526,0.0003728754,1.548133e-7,0.3329573,0.001045822,0.00001771986,0.00006554632,6.693659e-7,0.0001572575,0.0002020351,0.6643907,0.0001986484],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[4.105912e-7,0.9899687,0.0007516024,0.001549861,0.001074893,0.005849711,0.0001839477,0.00005393209,0.0005669325],"genre_scores_gemma":[0.00000344541,0.9908897,0.001796031,0.001086085,0.001325052,0.002289812,0.00007977045,0.0001371087,0.002392986],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5944983,"threshold_uncertainty_score":0.9999408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1239526854317568,"score_gpt":0.4831962870911889,"score_spread":0.3592436016594321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}