{"id":"W4401600549","doi":"10.1016/j.atherosclerosis.2024.117991","title":"Novel caffeine derivatives mitigate hyperlipidemia by reducing PCSK9 expression and secretion","year":2024,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"","keywords":"PCSK9; Hyperlipidemia; Caffeine; Secretion; Pharmacology; Medicine; Endocrinology; Chemistry; LDL receptor; Cholesterol; Lipoprotein; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004345896,0.0001832413,0.0003265736,0.00005987653,0.0001297628,0.0000619207,0.00004548863,0.0001340993,0.00005845242],"category_scores_gemma":[0.00006259001,0.0001431089,0.0001423853,0.000193588,0.00007744769,0.0001511617,0.00004794886,0.0002214436,0.00001543226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007488908,"about_ca_system_score_gemma":0.00005410672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003822153,"about_ca_topic_score_gemma":0.000002275907,"domain_scores_codex":[0.9987111,0.000050074,0.0002389497,0.0004418002,0.0002947823,0.0002632956],"domain_scores_gemma":[0.999372,0.00005121614,0.00003885368,0.000314725,0.00003479687,0.0001884131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001618347,0.00003508467,0.0006788139,0.0002875424,0.00007353524,0.000001745604,0.0005537799,0.000001481536,0.9742157,0.0001027297,0.001647431,0.02238599],"study_design_scores_gemma":[0.003144004,0.0006384061,0.05570172,0.006431421,0.0004384271,0.0001901406,0.000726001,0.002692235,0.8418625,0.0001354751,0.08734173,0.0006979506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843965,0.00732237,0.005794077,0.001194038,0.0002113606,0.0003883998,0.00002848321,0.0001943743,0.0004703785],"genre_scores_gemma":[0.9942554,0.001311315,0.003012158,0.0004060867,0.0003617942,0.00006017274,0.0000442103,0.0000555866,0.0004932332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1323532,"threshold_uncertainty_score":0.583581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085898359752434,"score_gpt":0.2610192561684038,"score_spread":0.2401602725708795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}