{"id":"W4401602224","doi":"10.1016/j.atherosclerosis.2024.118515","title":"Zodasiran silences hepatic ANGPTL3 leading to deep and durable reductions in atherogenic lipids and lipoproteins in mixed dyslipidemia patients: Final results from arches-2, double-blind period","year":2024,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Université du Québec à Chicoutimi","funders":"","keywords":"Dyslipidemia; Medicine; Double blind; Internal medicine; Cardiology; Gastroenterology; Endocrinology; Diabetes mellitus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000508449,0.000313593,0.0005531048,0.0004269957,0.0001236957,0.0001392466,0.000120308,0.000185434,0.00004466505],"category_scores_gemma":[0.0003338716,0.0002795719,0.00008924428,0.00088023,0.0001558088,0.0003243407,0.00009365865,0.0003671445,0.0000363639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001072006,"about_ca_system_score_gemma":0.00009663899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003428657,"about_ca_topic_score_gemma":0.003195606,"domain_scores_codex":[0.9976389,0.0001113548,0.0006438953,0.0008249181,0.0002926061,0.0004882746],"domain_scores_gemma":[0.9990706,0.0001942275,0.00007090427,0.0003593166,0.00004228039,0.0002625984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007589713,0.001391196,0.7228783,0.0006569167,0.0003013687,0.00001983262,0.07540271,0.0001750076,0.09640036,0.0003859167,0.0008443739,0.09395428],"study_design_scores_gemma":[0.02811261,0.0008131881,0.9508359,0.002668402,0.0003067177,0.000007967391,0.006157471,0.001341353,0.005801567,0.0005713774,0.00257655,0.0008069149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939668,0.002366652,0.00003120854,0.001748577,0.0004957017,0.001035763,0.00007512726,0.00008366766,0.0001965361],"genre_scores_gemma":[0.9968335,0.0007982296,0.001298698,0.0001901002,0.0002963508,0.0001987858,0.00006034271,0.00005240771,0.0002715898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2279576,"threshold_uncertainty_score":0.9999657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05089658467705977,"score_gpt":0.2920188464575791,"score_spread":0.2411222617805193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}