{"id":"W4401602224","doi":"10.1016/j.atherosclerosis.2024.118515","title":"Zodasiran silences hepatic ANGPTL3 leading to deep and durable reductions in atherogenic lipids and lipoproteins in mixed dyslipidemia patients: Final results from arches-2, double-blind period","year":2024,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Université du Québec à Chicoutimi","funders":"","keywords":"Dyslipidemia; Medicine; Double blind; Internal medicine; Cardiology; Gastroenterology; Endocrinology; Diabetes mellitus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006175007,0.0007535216,0.001594679,0.0002397801,0.0002594685,0.0005191383,0.0005416439,0.0007534053,0.004000751],"category_scores_gemma":[0.0002401084,0.0003443619,0.001057207,0.0001552843,0.0006153618,0.0005232079,0.00025723,0.001892103,0.0005331338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228976,"about_ca_system_score_gemma":0.0006278513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004846079,"about_ca_topic_score_gemma":0.001306986,"domain_scores_codex":[0.9998166,0.00004749556,0.00001672993,0.00003300266,0.00001819114,0.00006804092],"domain_scores_gemma":[0.9998807,0.00001291713,0.00002438482,0.00001975295,0.00001096042,0.000051259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6919819,0.02096166,0.0009057335,0.001475342,0.002141034,0.0003204644,0.0001245661,0.0002889485,0.2148812,0.0003920122,0.003536546,0.06299065],"study_design_scores_gemma":[0.6213072,0.2636849,0.01936994,0.0001278149,0.003238926,0.0006503668,0.0002839335,0.001323003,0.08113316,0.000496236,0.008270769,0.0001136245],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919659,0.004109069,0.0009464378,0.0004378186,0.000339637,0.0003728888,0.0005733662,0.0001863051,0.0010686],"genre_scores_gemma":[0.9872319,0.004278759,0.001783703,0.0005933822,0.0002223934,0.0006255503,0.0009384569,0.00004573163,0.004280149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004000751,"threshold_uncertainty_score":0.01338387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05089658467705977,"score_gpt":0.2920188464575791,"score_spread":0.2411222617805193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}