{"id":"W4401602358","doi":"10.1016/j.atherosclerosis.2024.118459","title":"Plozasiran (ARO-APOC3), an investigational RNAI therapeutic, demonstrates profound and durable reductions in APOC-3 and triglycerides (TG) in patients with severe hypertriglyceridemia (SHTG), SHASTA-2 final results","year":2024,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Hypertriglyceridemia; Medicine; Triglyceride; Internal medicine; Endocrinology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004633812,0.0008209794,0.0004331442,0.0003205185,0.0002926468,0.0005202722,0.0003167641,0.0006877384,0.003185044],"category_scores_gemma":[0.0001843423,0.0001673895,0.0005388249,0.0001487636,0.0002990447,0.0001756847,0.0002255314,0.001411811,0.0007632308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005079907,"about_ca_system_score_gemma":0.0006719409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006124962,"about_ca_topic_score_gemma":0.001932348,"domain_scores_codex":[0.9998581,0.00002647869,0.00001292487,0.0000261047,0.00004164746,0.00003472509],"domain_scores_gemma":[0.9999152,0.00001253069,0.00001597509,0.000007756805,0.00001883255,0.00002968798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.009678023,0.002741654,0.003210098,0.0006156136,0.0003816312,0.001727234,0.00007616243,0.0005549697,0.7341534,0.00216243,0.01483205,0.2298667],"study_design_scores_gemma":[0.005959875,0.01635768,0.02229449,0.0001061455,0.0008470428,0.005255435,0.00009990836,0.002032278,0.8492272,0.0007346309,0.09701575,0.00006957435],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8880644,0.02934941,0.01560497,0.008368282,0.001422379,0.001120979,0.003041661,0.001670443,0.05135741],"genre_scores_gemma":[0.9578045,0.009815589,0.006518522,0.002139422,0.0002731053,0.0003365233,0.003157648,0.0001023546,0.01985238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003185044,"threshold_uncertainty_score":0.01065499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936068270869527,"score_gpt":0.252814032554101,"score_spread":0.2234533498454057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}